Majka Laboratory Search Clinical Trials Find a Researcher Order a Test Our lab studies how mesenchymal progenitor cells (MPC) regulate lung microvascular function and dysregulated angiogenesis as well as how these processes contribute to the development or severity of chronic lung diseases (including fibrosis, emphysema as well as pulmonary hypertension). Lab Resources and Services Goodman 810-814 The Majka lab has identified and characterized a novel population of lung mesenchymal progenitor cells (MPC) as a regulator of microvascular function, structure and homeostasis. Her lab has developed techniques to isolate, differentiate and analyze murine and human mesenchymal stem cell phenotype, proliferation, inflammation, migration and matrix synthesis both in vitro and in vivo. To complement in vivo models of disease the laboratory has developed a method for mesenchymal, endothelial and smooth muscle differentiation of murine and human iPS cells. Current Projects Role of Lung MSC in Emphysema Lung MSC regulate Angiogenesis and Repair during Fibrosis Adult Mesenchymal Progenitor (MPC) Regulation of Early Pathogenesis in TSC , + × , Susan M. Majka, PhD, is a researcher at National Jewish Health. Dr. Majka is in the Division of Pulmonary, Critical Care and Sleep Medicine and the Department of Immunology and Genomic Medicine. View Full Profile Personnel Principal Investigator Susan Majka, PhD Professor of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Department of Biomedicl Research National Jewish Health, Denver CO Professor of Medicine, Division of Pulmonary & Critical Care Gates Center for Regenerative Medicine and Stem Cell Biology University of Colorado Health Sciences Center, Aurora CO Opportunities Motivated students and postdoctoral researchers are always welcome! Publications Yuan T, Volckaert T, Redente EF, Hopkins S, Klinkhammer K, Wasnick R, Chao CM, Yuan J, Zhang JS, Yao C, Majka S, Stripp BR, Günther A, Riches DWH, Bellusci S, Thannickal VJ, De Langhe SP. FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury. Stem Cell Reports. 2019 May 14;12(5):1041-1055. doi: 10.1016/j.stemcr.2019.04.003. Epub 2019 May 2. PubMed PMID: 31056475; PubMed Central PMCID: PMC6524168. Abstract Morrison RJ, Katsantonis NG, Motz KM, Hillel AT, Garrett CG, Netterville JL, Wootten CT, Majka SM, Blackwell TS, Drake WP, Gelbard A. Pathologic Fibroblasts in Idiopathic Subglottic Stenosis Amplify Local Inflammatory Signals. Otolaryngol Head Neck Surg. 2019 Jan;160(1):107-115. doi: 10.1177/0194599818803584. Epub 2018 Oct 16. PubMed PMID: 30322354; PubMed Central PMCID: PMC6389372. Abstract Bloodworth NC, Clark CR, West JD, Snider JC, Gaskill C, Shay S, Scott C, Bastarache J, Gladson S, Moore C, D'Amico R, Brittain EL, Tanjore H, Blackwell TS, Majka SM, Merryman WD. Bone Marrow-Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism. Circ Res. 2018 Dec 7;123(12):e51-e64. doi: 10.1161/CIRCRESAHA.118.313397. PubMed PMID: 30566041; PubMed Central PMCID: PMC6309812. Abstract View all Publications