Lahm Lab

Personnel

Tim Lahm

Tim Lahm, MD

Principal Investigator
303.270.2234
LahmT@NJHealth.org

Education

MD - University of Heidelberg Medical School, Heidelberg, 2000
Internship, Anesthesiology and Thoracic Surgery - University of Heidelberg Medical School, Heidelberg, Germany, 2002
Residency, Internal Medicine - Indiana University School of Medicine, 2005
Pulmonary/Critical Care Fellowship - Indiana University School of Medicine, 2008

Background

Tim is a physician scientist in the Division of Pulmonary, Critical Care and Sleep Medicine at National Jewish Health with a focus on the study of sexual dimorphisms in lung vascular remodeling and right ventricular (RV) adaptation in pulmonary hypertension (PH). He serves as the Director of Pulmonary Vascular Biology at NJH. The overall goal of his research is to identify novel therapeutic interventions for PH-induced RV and lung vascular dysfunction. In particular, he is interested in gender differences in PH and the role of sex hormones in PH and RV failure. His laboratory is studying mechanisms of how sex hormones such as 17β-estradiol affect lung and RV endothelial cell homeostasis as well as cardiomyocyte function during PH and RV failure development. A specific focus is on deciphering how estrogen receptor alpha promotes resilience to maladaptive RV remodeling by regulating angiogenesis, contractile signaling and inflammatory processes. Other areas of interest in Tim’s lab include studies of hypoxia-induced lung vascular and RV remodeling, neurohormonal signaling in the RV, exercise effects on RV function, and novel PH phenotypes in the veteran population. Tim’s lab recently expanded its studies of sexually dimorphic lung diseases to study androgen signaling in asthma and to identify mechanisms of how androgens modulate airway epithelial cell function. Tim’s research is funded through the NIH and the Department of Veterans Affairs. He is heavily involved with multiple professional societies and currently serves as the Chair of the American Thoracic Society Pulmonary Circulation Assembly. He is particularly proud of his mentoring record and feels fortunate that he is able to work with outstanding students, postdocs, fellows and junior faculty. Seeing these people develop their careers and exhibit personal growth is the most rewarding aspect of his career.

Tim’s clinical interest is in PH, RV failure and lymphangioleiomyomatosis - conditions that exhibit significant gender biases and that disproportionally affect women. He is also passionate about critical care medicine and provides care to critically ill patients in the intensive care unit.

When he is not writing about himself in the third person, Tim enjoys mountain biking, paddle boarding, sailing, skiing, hiking, camping, cooking, exploring microbreweries, and spending time with his wife, three kids, two dogs and cat (all of which are foodicisits).

 

Simon Bousseau, PhD

Simon Bousseau, PhD

Postdoctoral Research Fellow
303.270.2234
BousseauS@NJHealth.org

Education

University of Angers, Angers, France, 2012-2018 
Institut Catholique d’Etudes superieures, La Roche sur Yon, France, 2010-2012 

Background

Simon has completed his PhD in France in 2018, describing the beneficial properties of a pharmacological compound, Phostin 3.1a, which increases angiogenesis and reverses the metabolic Warburg effect in Glioblastoma associated endothelial cells. After two years in industry, he has joined the Lahm lab in January 2021 to study the role of estrogen on both angiogenesis and endothelial metabolism in the context of pulmonary hypertension. 

 

Rafael Fais, PhD

Rafael Fais, PhD

Postdoctoral Research Fellow
sobranofaisr@njhealth.org
303.270.2234

Education

University of Sao Paulo, Ribeirao Preto Medical School, PHD, 2016-2020 
University of Sao Paulo, Ribeirao Preto Medical School, MS, 2014-2016 
University of Sao Paulo, Ribeirao Preto Medical School, BS, 2016-2020 

Background

Rafael is now a postdoctoral research fellow at National Jewish Health. While he was doing his bachelor’s at Ribeirao Preto Medical School, his under-graduation work focused on the central mechanisms of pain control mainly the descending serotoninergic and noradrenergic pathways. Subsequently, on his master’s worked he worked on the endothelin-1 induced inflammation in erectile tissue, focused on the NLRP3 inflammasome pathway. During his PhD he also worked on investigating endothelin-1-induced NLRP3 activation in DOCA/salt model of hypertension, focused on the erectile and vascular function impairment promoted by the NLRP3 inflammasome. Additionally, he has been working on the crosstalk between sex hormone signaling and NLRP3 inflammasome in right ventricle in pulmonary hypertension.

 

Jiajun Li, MS

Jiajun Li, MS

Graduate Student
jiajun.li@cuanschutz.edu
303.270.2234

Education

University of Colorado | Anschutz Medical Campus, 2021-current 
Illinois Institute of Technology, MS, 2017 
Ocean University of China, BS, 2015 

Background

Jiajun is now a PhD at University of Colorado | Anschutz Medical Campus. While he was doing his master’s at Illinois Institute of Technology, his work focused on an isoform of Bax (BaxΔ2) and its microsatellite variation in colon cancer cell lines. He subsequently worked on a BMPR2 mutation found in patients with hereditary pulmonary hypertension and investigated the effects of fibroblasts on vascular remodeling. He has also been working on investigating the effects of pre-conditioning stimulus on the metabolic properties of iPSC-CM which may help to enhance cardiac regeneration. Now, his project is focused on effects of estrogen receptor alpha (ERα) on endothelial cell function in right heart failure. 

 

Avram Walts

Avram Walts, MS

Senior Professional Research Assistant
Laboratory Manager

303.270.2234
WaltsA@NJHealth.org

Education

B.S., UCLA, 1996
M.S., University of Michigan, 1999

Background

Avram recently joined the Lahm Lab as the lab manger. He previously worked on Idiopathic Pulmonary Fibrosis and Stat3 signaling at both the University of Colorado and the National Institutes of Health. He and his wife can often be found outdoors hiking, camping, or skiing. Avram is also an amateur photographer.

 

   

Erica das Neves Palotta Fais

Erica das Neves Palotta Fais

ericapalotta1@hotmail.com

Education

Londrina State University, Nursing Department l, Londrina, Parana - Brazil, B.Sc. (Nursing) 2005-2008
Sagrado Coracao University, Bauru, São Paulo - Brazil, Specialization (Occupational Nursing), 2009-2010
Faculty of Philosophy Science and Letters Of Ibitinga, Ibitinga, Sao Paulo - Brazil, B.Sc. (Administration), 2012-2015
Faculty Dom  Alberto| Santa Cruz do Sul, RS – Brazil, Specialization (Health and Social Welfare), 2020

Background

Erica is now a volunteer at National Jewish Health. She worked as a nurse for eleven years in Brazil. She has work experience in Emergency Services, Primary care, and Family Health Strategies. During her graduation in nursing, she studied the prevention of pressure ulcers using pressure-reducing devices.

 

   

Lab Alumni

Andrea Frump, PhD, Indiana University
James Hester, PhD, Labcorp Drug Development, IN
Sheila Krishnan, MD, Spectrum Health, MI
Kara Goss, MD, UT Southwestern
Anthony Cucci, MD, Cleveland Clinic, OH
Mona Selej, MD, Janssen Pharmaceutical Companies of Johnson & Johnson, CA