The Lahm laboratory is studying mechanisms of how sex hormones such as 17β-estradiol affect lung and RV endothelial cell homeostasis as well as cardiomyocyte function during PH and RV failure development. A specific focus is on deciphering how estrogen receptor alpha promotes resilience to maladaptive RV remodeling by regulating angiogenesis, contractile signaling and inflammatory processes.
Other areas of interest in the Lahm lab include studies of hypoxia-induced lung vascular and RV remodeling in the perinatal period and throughout the lifespan, neurohormonal signaling in the RV, exercise effects on RV function, and novel PH phenotypes in the veteran population. The Lahm lab recently expanded its studies of sexually dimorphic lung diseases to study androgen signaling in asthma and to identify mechanisms of how androgens modulate airway epithelial cell function.
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Resources & Services
Our laboratory is studying:
- mechanisms of how sex hormones such as 17β-estradiol affect lung and RV endothelial cell homeostasis as well as cardiomyocyte function during PH and RV failure development
- mechanisms of how estrogen receptor alpha promotes resilience to maladaptive RV remodeling by regulating angiogenesis, contractile signaling and inflammatory processes
- mechanisms of hypoxia-induced lung vascular and RV remodeling in the perinatal period and throughout the lifespan
- mechanisms of how androgens modulate airway epithelial cell function in severe asthma
- neurohormonal signaling in the RV
- exercise effects on RV function
- novel PH phenotypes in the veteran population
We offer expertise, techniques and equipment to study these topics as well as sex biases in cardiopulmonary disease in general.
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Frump AL, Albrecht ME, Yakubov B, Breuils Bonnet S, Nadeau V, Tremblay E, Potus F, Omura J, Cook T, Fisher A, Rodriguez BE, Brown RD, Stenmark KR, Rubinstein CD, Krentz K, Tabima DM, Li R, Sun X, Chesler NC, Provencher S, Bonnet S, Lahm T. 17β-estradiol and estrogen receptor-α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin. J Clin Invest. 2021 Mar 15;131(6):e129433. doi: 10.1172/JCI129433. PMID: 33497359
Lahm T, Hess E, Barón AE, Maddox TM, Plomondon ME, Choudhary G, Maron BA, Zamanian RT, Leary PJ. Renin-Angiotensin-Aldosterone System Inhibitor Use and Mortality in Pulmonary Hypertension: Insights from the Veterans Affairs CART Database. Chest. 2021 Apr;159(4):1586-1597. doi: 10.1016/j.chest.2020.09.258. PMID: 33031831
Tello K, Richter MJ, Yogeswaran A, Ghofrani HA, Naeije R, Vanderpool R, Gall H, Tedford RJ, Seeger W, Lahm T. Sex Differences in Right Ventricular-pulmonary Arterial Coupling in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2020 Oct 1;202(7):1042-1046. PMID: 32501730
Frump AL, Selej MA, Wood J, Albrecht M, Yakubov B, Petrache I, Lahm T. Hypoxia up-regulates estrogen receptor β in pulmonary artery endothelial cells in a HIF-1α dependent manner. Am J Resp Cell Mol Biol. 2018 Jul;59(1):114-126. PMID: 29394091
Lahm T, Albrecht M, Fisher AJ, Selej M, Patel N, Brown JA, Justice MJ, Brown MB, Van Demark M, Trulock KM, Dieudonne D, Reddy JG, Presson RG, Petrache I. 17-Beta Estradiol Attenuates Hypoxic Pulmonary Hypertension Via Estrogen Receptor-Mediated Effects. Am J Respir Crit Care Med. 2012 May 1;185(9):965-80. PMID: 25713318
Krishnan S, Stearman RS, Zeng L, Fisher AJ, Mickler EA, Rodriguez BH, Simpson ER, Cook TG, Slaven JE, Ivan M, Geraci MW, Lahm T, Tepper RS. Transcriptomic Modifications in Developmental Cardiopulmonary Adaptations to Chronic Hypoxia Using a Murine Model of Simulated High Altitude Exposure. Am J Physiol Lung Cell Mol Physiol. 2020. doi:10.1152/ajplung.00487.2019. PMID: 32639867
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