The Lahm laboratory is studying mechanisms of how sex hormones such as 17β-estradiol affect lung and RV endothelial cell homeostasis as well as cardiomyocyte function during PH and RV failure development. A specific focus is on deciphering how estrogen receptor alpha promotes resilience to maladaptive RV remodeling by regulating angiogenesis, contractile signaling and inflammatory processes.
Other areas of interest in the Lahm lab include studies of hypoxia-induced lung vascular and RV remodeling in the perinatal period and throughout the lifespan, neurohormonal signaling in the RV, exercise effects on RV function, and novel PH phenotypes in the veteran population. The Lahm lab recently expanded its studies of sexually dimorphic lung diseases to study androgen signaling in asthma and to identify mechanisms of how androgens modulate airway epithelial cell function.
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Resources & Services
Our laboratory is studying:
- mechanisms of how sex hormones such as 17β-estradiol affect lung and RV endothelial cell homeostasis as well as cardiomyocyte function during PH and RV failure development
- mechanisms of how estrogen receptor alpha promotes resilience to maladaptive RV remodeling by regulating angiogenesis, contractile signaling and inflammatory processes
- mechanisms of hypoxia-induced lung vascular and RV remodeling in the perinatal period and throughout the lifespan
- mechanisms of how androgens modulate airway epithelial cell function in severe asthma
- neurohormonal signaling in the RV
- exercise effects on RV function
- novel PH phenotypes in the veteran population
We offer expertise, techniques and equipment to study these topics as well as sex biases in cardiopulmonary disease in general.
View Resources and Services for more details
Publications
Frump AL, Yakubov B, Walts A, Fisher AJ, Cook T, Chesler NM, Lahm T. Estrogen receptor α exerts endothelial-protective effects and attenuates pulmonary hypertension. Am J Resp Cell Mol Biol 2023.
Bousseau S, Sobrano Fais R, Gue S, Frump AL, Lahm T. Pathophysiology and new advances in pulmonary hypertension. BMJ Medicine 2023.
Sangam S, Sun X, Schwantes-An TH, Yegambaram M, Lu, Q, Shi Y, Cook T, Fisher A, Frump AL, Coleman A, Sun Y, Liang S, Crawford H, Lutz KA, Maun AD, Pauciulo MW, Karnes JH, Chaudhary KR, Stewart DJ, Langlais PR, Jain M, Alotaibi M, Lahm T, Jin Y, Gu H, Tang H, Nichols WC, Black SM, Desai AA. SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics. Am J Respir Crit Care Med. 2023.
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