Current Projects and Grant Support Search Clinical Trials Find a Researcher Order a Test RO1 AI070175 9/01/08 – 8/31/12 NIH/NIAID (PI: CHU) Effects of Allergic Inflammation on TLR2 Signaling and Mycoplasma Infection The major goals of this project are to determine the role of allergic inflammation in TLR2 signaling of airway epithelial cells and dendritic cells in response to Mycoplasma infection and to determine the impact of low level of bacterial infection on Th2 differentiation of T cells through modulation of dendritic cells. RO1 HL088264 12/10/08 – 11/30/12 NIH/NHLBI (PI: CHU) SPLUNC1 Protein in Host Defense Against Mycoplasma Pneumoniae Infection The major goal is to study both the function and regulation of SPLUNC1 protein against bacterial (i.e., Mycoplasma pneumoniae) infection of an airway Th2 cytokine milieu. RO1 HL088264 – Supplement 7/01/09 – 6/30/11 NIH/NHLBI (PI: CHU) Chu (PI): SPLUNC1 Supplement R01 – NIH/NHLBI SPLUNC1 Protein in Host Defense Against Mycoplasma Pneumoniae Infection The major goal of this administrative supplement is to generate SPLUNC1 knockout mice, and use these mice to examine the in vivo function of SPLUNC1 in host defense against bacterial infections. Research Grant 7/01/08 – 6/30/11 Flight Attendant Medical Research Institute (FAMRI) (PI: CHU) Host Defense Functions of Airway Epithelial Cells in COPD The overall objective of this project is to determine the molecular mechanisms responsible for impaired airway epithelial defense against bacteria in patients with chronic obstructive pulmonary disease (COPD). Specifically, the role of prostaglandin E2 (PGE2) pathway of cigarette smoke exposure will be studied in human brushed bronchial epithelial cells from COPD patients and control subjects.