Our lab performs basic & translational research to understand the role of monocytes and macrophages in modulating airway inflammation in people with cystic fibrosis (CF).

 

Lab Resources & Services

The lab is located on the 5th floor of the Smith Building.

 

Current Projects

  1. Characterization of macrophage populations in the CF airway, and investigations into how these cells modulate inflammation.

    • How much heterogeneity is present in airway macrophage populations?

    • Does the abundance of populations of macrophage shift during pulmonary exacerbations?

    • How do various medications affect airway macrophages phenotypes?

  2. Identification of novel therapeutics / anti-inflammatory medications for people with CF (and other chronic inflammatory airways diseases)

  3. Investigations into the role of macrophages in susceptibility of people with CF to NTM infection.

 

View Diagrams

Personnel

Principal Investigator:
Katherine “Katie” Hisert, MD, PhD
 
Post-doctoral fellow:
Ari Simenauer, PhD
 
Research Technicians:
Alma Ochoa
Krystin Skinner

 

Collaborators

Publications

Hisert KB*, Heltshe SL*, Pope C*, Jorth P, Wu X, Edwards RM, Radey M, Accurso FJ, Wolter DJ, Cooke G, Adam RJ, Carter S, Grogan B, Launspach JL, Donnelly SC, Gallagher C, Bruce JE, Stoltz D, Welsh MJ, Hoffman LR§, McKone EF§, Singh PK§. “Restoring CFTR function reduces airway bacterial burden and inflammation in people with CF and chronic lung infections.” AJRCCM, 195(12): 1617-1628 (2017), PMID: 28222269 *these authors contributed equally. §these authors contributed equally.

Hisert KB, Liles WC, Manicone AM. “A flow cytometric method for isolating cystic fibrosis airway macrophages from expectorated sputum.” AJRCMB. 61(1): 42-50 (2019), PMID: 30742539.

View All Publications