Day Laboratory

Our laboratory is interested in the role of oxidative stress in lung disease and antioxidant adaptive responses that the lung uses to prevent oxidative stress. In this regard, we are focused on lung thiols and their roles in preventing oxidative injury and in modulating inflammatory host defense responses. We also have active programs developing pharmacological approaches that either supplement antioxidant capacity or stimulate endogenous pathways to increase antioxidant capacity in the lung. Major lung diseases we are currently working on include acute lung injury due to chemical weapons (sulfur mustard gas and chlorine gas), cystic fibrosis, and asthma and interstitial lung disease associated with environmental particulate matter.

    

Lab Resources and Services

Dr. Brian Day’s laboratory is located on the 4th floor of the Smith building on National Jewish Health’s campus. Learn more.

    

Current Projects

   

Personnel

  • Former Graduate Students
    Reena Berman, PhD (Associate Regional Medical Director at Novartis Gene Therapies)
    Joshua Chandler, PhD (Assistant Professor in the Department of Pediatrics at Emory University)
    Cameron McElroy, PhD (Principal Scientist at Novartis Institutes for Biomedical Research)
    Neal Gould, PhD (Senior Scientist at Tegmine Therapeutics)
    Heather Brechbuhl, PhD (Instructor at University of Colorado)
    Chirag Kariya, PhD (Manager at Provincial Clinical Trials)

  • Former Post-Doctoral Fellows
    Leonard Velsor, PhD (Senior Counsel at Eastman Chemical Company)
    Remy Kachadourian, PhD (Director of Innovation and Quality at Schwazze)
    Preston Bratcher, PhD (Assistant Professor in the Department of Pediatrics at National Jewish Health)

 

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Publications

Day, B.J., Huang, J., Barkes, B.Q., Gillespie, M., Li, L., and Maier, L. 5-Aminosalicylic acid modulates the immune response in chronic beryllium disease subjects. Lung 196:103-114, 2018.

Liang, L.P., Pearson-Smith, J.N., Huang, J., McElroy, P., Day, B.J., and Patel, M. Neuroprotective effects of AEOL10150 in a rat organophosphate model. Toxicol. Sci. 162:611-621, 2018.

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Lab Activities

Day Lab Personnel

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