The goal of our lab research is to perform basic and translational research to understand the mechanisms of airway diseases, and discover new therapeutic targets. Our major research interests include the role of respiratory pathogens (viruses and bacteria) in asthma and chronic obstructive pulmonary disease (COPD) exacerbations. We use human biological samples, cell culture and animal models coupled with cutting-edge technologies (e.g. conditional gene knockout, CRISPR/Cas9, single cell RNA-sequencing) to determine host-pathogen interactions, and the mechanisms by which infections reshape the innate immune system and contribute to asthma and COPD pathobiology.
View All Publications
E-Cigarettes and Cardiopulmonary Health. Tarran R, Barr RG, Benowitz NL, Bhatnagar A, Chu HW, Dalton P, Doerschuk CM, Drummond MB, Gold DR, Goniewicz ML, Gross ER, Hansel NN, Hopke PK, Kloner RA, Mikheev VB, Neczypor EW, Pinkerton KE, Postow L, Rahman I, Samet JM, Salathe M, Stoney CM, Tsao PS, Widome R, Xia T, Xiao D, Wold LE.
Very Late Antigen-4: A Novel Receptor for Club Cell Secretory Protein 16 to Control Inflammation. Chu HW, Schaunaman N.Am J Respir Crit Care Med. 2021 Jan 15. doi: 10.1164/rccm.202012-4467ED. Online ahead of print.PMID: 33449844 No abstract available.
The Chu Laboratory offers several unique research methods and animal models for pulmonary basic science research. Learn more.