Bowler Laboratory Search Clinical Trials Find a Researcher Order a Test Russell Bowler, M.D., Ph.D. obtained a B.S. in mathematical and computational sciences from Stanford University, a M.D. from the University of California at San Francisco (UCSF), and a Ph.D. in Cell and Developmental Biology from the University of Colorado (CU). He completed his internal medicine residency at UCSF and a pulmonary and critical care fellowship from CU. The mission of our lab is to understand the mechanisms of how inhaled smoke (cigarette or cannabis smoke and vaping) leads to the development of chronic obstructive pulmonary disease (COPD), the third leading cause of death in the United States. We have generated genetic, genomic, metabolic profiles on 10,000 subjects in the NIH sponsored COPDGene and SPIROMICS cohort and use these Omics data to identify novel diagnostic and therapeutic targets. Our laboratory also uses mouse models to study the mechanisms of smoke induced lung disease. We also use wearable sensors and artificial intelligence/machine learning to develop algorithms for at-home detection of COPD exacerbations. Lab Resources and Services The Bowler Laboratory offers high-throughput genomic, proteomic, and metabolic profiling. Additionally, oxidative stress, antioxidant measurements, and translational models in COPD (cigarette smoke extract, whole smoke). Current Projects GWAS, Genome, Metabolome and proteome profiles of emphysema and airway disease Cigarette smoke induces endogenous oxidant injury Vaping effects on young adults Using wearable sensors and AI/ML to detect COPD exacerbations while at home New biologic therapy for COPD Currently Enrolling Research Projects Study of people ages 30-55 who have smoked tobacco cigarettes: NIH SOURCE study: https://sourcestudy.net/source/clinicalSites/National%20Jewish%20Health Study of people who vape ages 18-25: click here; contact Engel Elena <engele@njhealth.org> Study of people with COPD and two exacerbations in the past year: email "Maria Saucedo Garcia," <SAUCEDOGARCIAM@njhealth.org> Study of people with COPD with a history of one exacerbation who want to use wearable sensors such as an Apple Watch: contact contact Engel Elena <engele@njhealth.org> Russell P. Bowler, MD, PhD + × Russell P. Bowler, MD, PhD Russell P. Bowler, MD, is a pulmonologist at National Jewish Health. Dr. Bowler is in the Division of Pulmonary, Critical Care and Sleep Medicine. Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine View Full Profile Patient Rating 4.4 out of 5 stars Make an Appointment Personnel Principal Investigator Russell P. Bowler, MD, PhD Lab Researchers Elena Engel, BS, CRC II Ari McCallum, BS, CRC II Claire Guo, MS, Analyst Sophia Addi, MS, Laboratory Technician Andrew Hill, MS, Analyst Postdoctoral fellow Lisa Ruvuna, MD Collaborators Publications Serban KA, Pratte KA, Strange C, Sandhaus RA, Turner AM, Beiko T, Spittle DA, Maier L, Hamzeh N, Silverman EK, Hobbs BD, Hersh CP, DeMeo DL, Cho MH, Bowler RP. Unique and shared systemic biomarkers for emphysema in Alpha-1 Antitrypsin deficiency and chronic obstructive pulmonary disease. EBioMedicine. 2022 Oct;84:104262. doi: 10.1016/j.ebiom.2022.104262. Epub 2022 Sep 22. PubMed PMID: 36155958; PubMed Central PMCID: PMC9507992. More Publications