Bowler Laboratory

Russell Bowler, M.D., Ph.D. obtained a B.S. in mathematical and computational sciences from Stanford University, a M.D. from the University of California at San Francisco (UCSF), and a Ph.D. in Cell and Developmental Biology from the University of Colorado (CU). He completed his internal medicine residency at UCSF and a pulmonary and critical care fellowship from CU.

The mission of our lab is to understand the mechanisms of how cigarette smoke leads to the development of chronic obstructive pulmonary disease (COPD), the third leading cause of death in the United States. We have generated genetic, genomic, metabolic profiles on 10,000 subjects in the NIH sponsored COPDGene cohort and use these Omics data to identify novel diagnostic and therapeutic targets. Our laboratory also uses mouse models to study the mechanisms of cigarette smoke induced lung disease.

 

Lab Resources and Services

The Bowler Laboratory offers markers of genetic, genomic, proteomic, and metabolic profiling. Additionally, oxidative stress, antioxidant measurement, 2-D gel electrophoresis, and translational research in COPD.

 

Current Projects

  • GWAS, Genome, Metabolome and proteome profiles of emphysema and airway disease
  • Cigarette smoke induces endogenous oxidant injury
  • Textural Approach to Quantification of Diffuse Lung Disease on CT

 

Personnel

Collaborators

Publications

More, J.M., D.R. Voelker, L.J. Silveira, M.G. Edwards, E.D. Chan, and R.P. Bowler, Smoking reduces surfactant protein D and phospholipids in patients with and without chronic obstructive pulmonary disease. BMC Pulm Med. 10: p. 53. Abstract

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