Current Projects and Grant Support Search Clinical Trials Find a Researcher Order a Test NIH RO1 ES017582-01 Targeting Oxidative Stress in Chronic Beryllium Disease P.I. Brian J. Day Total Award Period: 7/01/09 – 6/30/14 Goals: To (1) examine the effect of beryllium on APC antioxidant status and oxidative response; (2) examine the effect of altered antioxidant status on antigen presentation by APC and T cell activation responses to beryllium; (3) examine the role of oxidative stress on antigen presentation by APC and T cell activation responses to beryllium. NIH RO1 HL084469 Adaptive glutathione responses to cigarette smoke in COPD P.I. Brian J. Day Total Award Period: 12/1/07 – 11/31/11 Goals: The overall goal of this application is to determine the role of glutathione (GSH) adaptive responses to cigarette smoke which is a major risk factor in chronic obstructive pulmonary disease (COPD). The specific aims are to: 1) examine mechanism(s) responsible for GSH adaptive responses stimulated by cigarette smoke; 2) examine whether defective extracellular GSH adaptive responses contributes to enhanced cigarette smoke-induced lung epithelial cell oxidation and injury upon exposure to extracellular oxidants; 3) Examine whether defective GSH transport sensitizes the lung to cigarette smoke-induced oxidative stress and inflammation. NIH U54 ES015678-01 (CounterACT) Novel Antioxidant Therapeutics for Sulfur Mustard Toxicity Director Carl White Project 2 Leader Brian J. Day Total Award Period: 9/15/06 – 9/14/11 The overall goals of this project are to develop an effective treatment for mustard gas-induced injury. The specific aims are to: 1) determine the efficacy of catalytic antioxidants in rat and human models of CEES-induced lung injury; 2) determine the efficacy of catalytic antioxidants in mouse and human models of CEES-induced dermal injury; 3) develop and characterize a new class of catalytic antioxidants, the linear tetrapyrroles.