Publications

Abstracts available at Pub Med.

Gally F, Sasse SK, Kurche JS, Gruca MA, Cardwell JH, Okamoto T, Chu HW, Hou X, Poirion OB, Buchanan J, Preissl S, Ren B, Colgan SP, Dowell RD, Yang IV, Schwartz DA, Gerber AN. The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling. JCI Insight. 2021;6(2). Abstract

Mostafa MM, Bansal A, Michi AN, Sasse SK, Proud D, Gerber AN, Newton R. Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells. J Biol Chem. 2020. Abstract

Altonsy MO, Kurwa HA, Lauzon GJ, Amrein M, Gerber AN, Almishri W, Mydlarski PR. Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-kappaB inflammatory signaling pathway in human skin cells. Immun Inflamm Dis. 2020;8(1):62-79. Abstract

Sasse SK, Gruca M, Allen MA, Kadiyala V, Song T, Gally F, Gupta A, Pufall MA, Dowell RD, Gerber AN. Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression. Genome Res. 2019;29(11):1753-65. Abstract

Sasse SK, Gerber AN. Old Cells in Young Airway Smooth Muscle: Does Neonatal Senescence Cause Lifelong Airway Obstruction? Am J Respir Cell Mol Biol. 2019;61(1):3-4. Abstract

Riemondy KA, Jansing NL, Jiang P, Redente EF, Gillen AE, Fu R, Miller AJ, Spence JR, Gerber AN, Hesselberth JR, Zemans RL. Single cell RNA sequencing identifies TGFbeta as a key regenerative cue following LPS-induced lung injury. JCI Insight. 2019;5. Epub 2019/03/27. doi: 10.1172/jci.insight.123637. Abstract

Britt RD, Jr., Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-alpha and IFN-gamma promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019;316(1):L71-L81. Abstract

Evans CM, Seibold MA, Gerber AN. SPDEFending the Lung through Mucin Expression. Am J Respir Cell Mol Biol. 2018;59(3):287-8. Abstract

Rider CF, Altonsy MO, Mostafa MM, Shah SV, Sasse S, Manson ML, Yan D, Karrman-Mardh C, Miller-Larsson A, Gerber AN, Giembycz MA, Newton R. Long-Acting beta2-Adrenoceptor Agonists Enhance Glucocorticoid Receptor (GR)-Mediated Transcription by Gene-Specific Mechanisms Rather Than Generic Effects via GR. Mol Pharmacol. 2018;94(3):1031-46. Abstract

Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol. 2018;142(4):1173-84. Abstract

Swaminathan S, Qirko K, Smith T, Corcoran E, Wysham NG, Bazaz G, Kappel G, Gerber AN. A machine learning approach to triaging patients with chronic obstructive pulmonary disease. PLoS One. 2017;12(11):e0188532. Abstract

Sasse SK, Kadiyala V, Danhorn T, Panettieri RA, Jr., Phang TL, Gerber AN. Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy. Am J Respir Cell Mol Biol. 2017;57(2):226-37. Abstract

Helling BA, Gerber AN, Kadiyala V, Sasse SK, Pedersen BS, Sparks L, Nakano Y, Okamoto T, Evans CM, Yang IV, Schwartz DA. Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017;57(1):91-9. Abstract

Newton R, Shah S, Altonsy MO, Gerber AN. Glucocorticoid and cytokine crosstalk: Feedback, feedforward, and co-regulatory interactions determine repression or resistance. J Biol Chem. 2017;292(17):7163-72. Abstract

Katial RK, Bensch GW, Busse WW, Chipps BE, Denson JL, Gerber AN, Jacobs JS, Kraft M, Martin RJ, Nair P, Wechsler ME. Changing Paradigms in the Treatment of Severe Asthma: The Role of Biologic Therapies. J Allergy Clin Immunol Pract. 2017;5(2S):S1-S14. Abstract

Altonsy MO, Mostafa MM, Gerber AN, Newton R. Long-acting beta2-agonists promote glucocorticoid-mediated repression of NF-kappaB by enhancing expression of the feedback regulator TNFAIP3. Am J Physiol Lung Cell Mol Physiol. 2017;312(3):L358-L70. Abstract

Gerber AN. Measuring safety of inhaled corticosteroids in asthma. Ann Allergy Asthma Immunol. 2016;117(6):577-81. Abstract

Sasse SK, Altonsy MO, Kadiyala V, Cao G, Panettieri RA, Jr., Gerber AN. Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression. Am J Physiol Lung Cell Mol Physiol. 2016;311(2):L421-32. Abstract

Kadiyala V, Sasse SK, Altonsy MO, Berman R, Chu HW, Phang TL, Gerber AN. Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-kappaB Orchestrates Anti-inflammatory Effects. J Biol Chem. 2016;291(24):12673-87. Abstract

Kraft M, Gerber AN, Szefler SJ, Wechsler ME. Introduction to the 58th Annual Thomas L. Petty Aspen Lung Conference: Asthma 2015: Mechanisms to Personalized Medicine. Ann Am Thorac Soc. 2016;13 Suppl 1:S23-4. Abstract

Kadiyala V, Sasse SK, Altonsy MO, Phang TL, Gerber AN. Cistrome Analysis of Glucocorticoid Receptor Activity in Bronchial Epithelial Cells Defines Novel Mechanisms of Steroid Efficacy. Ann Am Thorac Soc. 2016;13 Suppl 1:S103. Abstract

Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM. Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program. Proc Natl Acad Sci U S A. 2015;112(49):E6780-9. Abstract

Sasse SK, Zuo Z, Kadiyala V, Zhang L, Pufall MA, Jain MK, Phang TL, Stormo GD, Gerber AN. Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops. J Biol Chem. 2015;290(32):19756-69. Abstract

Gerber AN. Glucocorticoids and the Lung. Adv Exp Med Biol. 2015;872:279-98. Abstract

Sasse, SK and Gerber A.N. Feed-forward transcriptional programming by nuclear receptors: Regulatory principles and therapeutic implications. Pharmacology and Therapeutics. 2014 Aug 25. Abstract

Altonsy O, Sasse SK, Tzu P, and Gerber A.N. Context-dependent Cooperation Between NF-kB and the Glucocorticoid Receptor at a TNFAIP3 Enhancer: A Mechanism to Maintain Negative Feedback Control of Inflammation. J Biol Chem. 2014 Mar 21;289(12):8231-9. Abstract

Sasse SK, Mailloux C, Barczak A, Wang Q, Altonsy O, Jain MK, Haldar SM and Gerber A.N. The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed forward circuitry. Mol Cell Biol. 2013 Jun;33(11):2104-15. Abstract

Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami   D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A. 2012 Apr 9. Abstract

Masuno K, Haldar SM, Jeyaraj D, Mailloux C, Huang X, Panettieri Jr RA, Jain MK,    Gerber A.N. 2011 Expression profiling identifies Klf15 as a glucocorticoid target that regulates Airway Hyperresponsiveness. Am J Respir Cell Mol Biol. 2011. Sep;45(3):642-9.  Abstract

Gerber, A.N., Masuno K., Diamond M.I. 2009 . Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening. Proc Natl Acad Sci U S A. 2009 Mar  24;106(12):4929-34. Abstract

Gerber, A.N., Wilson C., Li, Y.J, Chuang, P.T. 2007. The Hedgehog regulated oncogenes Gli1 and Gli12 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation. Oncogene. 2007 Feb 22;26(8):1122-36. Abstract

Yun A.J., Lee P.Y., and Gerber A.N. 2006. Perspective. Integrating systems biology and medical imaging: understanding disease distribution in the lung model. Am. J. Roentgenol. April; 186(4):925-30. Abstract

Cook, D.L., Gerber, A.N., Tapscott, S.J. 1998. Modeling stochastic gene expression: Implications for haploinsufficiency. Procedings of the National Academy of Sciences, Dec 22; 26: 15641-6. Abstract

Gredinger, E., Gerber, A.N., Tamir, Y., Tapscott, S.J., Bengal, E. 1998. Mitogen-activated protein kinase pathway is involved in the differentiation of muscle cells. Journal of Biological Chemistry, Apr 24; 273: 10436-10444. Abstract

Otten. A.D., Firpo, E.J., Gerber, A.N., Brody, L.L, Roberts, J.M., Tapscott, S.J. 1997. Inactivation of MyoD mediated expression of p21 in tumor lines. Cell Growth and Differentiation, Nov 8; 11: 1151-60. Abstract

Gerber A.N., Klesert, T.R., Bergstrom, D.A., Tapscott, S.J. 1997. Two domains of MyoD mediate transcriptional activation of genes within repressive chromatin: a mechanism for lineage determination in myogenesis. Genes and Development, Feb 15; 11: 436-50.  Abstract

Gerber A.N. and Tapscott S.J. 1996. Tumor cell complementation groups based on myogenic potential: evidence for inactivation of loci required for basic helix-loop-helix protein activity. Molecular and Cellular Biology, Jul 16; 7: 3901-8. Abstract