Gerber Laboratory

The Gerber lab seeks to bridge the gap between the basic science of glucocorticoid receptor (GR) biology, and clinical therapeutics in pulmonary disease. To accomplish this, we are investigating two basic aspects of glucocorticoid action in the lung. In one area of study, we are investigating the lung-specific function of two members of the Kruppel-like family of transcription factors that are regulated by glucocorticoids, Klf9 and Klf15. In another approach, we are decoding the primary and secondary transcriptional responses to glucocorticoids in airway cells. Through developing a greater understanding of these two aspects of GR function, we seek to identify novel candidates for therapeutic targeting to treat lung disease.

Lab Resources and Services

The Gerber laboratory is located on the 6th floor of the Goodman building on the main campus of National Jewish Health. Learn more.

Current Projects

• Klf15 and airway smooth muscle function
• Dynamics of the transcriptional response to glucocorticoids in airway cells
• Multiplexed high throughput screen development and implementation

Personnel

• Principal Investigator
  Anthony N. Gerber, MD, PhD
• Lab Members
  Sarah Sasse, PhD
  Vaneela Kadiyala, PhD
• Alumni
  Christina M. Mailloux, PhD
  Kiriko Masuno
  Omar Altonsy

Collaborators

Publications

Altonsy O, Sasse SK, Tzu P, and Gerber A.N. Context-dependent Cooperation Between NF-kB and the Glucocorticoid Receptor at a TNFAIP3 Enhancer: A Mechanism to Maintain Negative Feedback Control of Inflammation. J Biol Chem. 2014 Mar 21;289(12):8231-9. Abstract

Sasse, SK and Gerber A.N. Feed-forward transcriptional programming by nuclear receptors: Regulatory principles and therapeutic implications. Pharmacology and Therapeutics. 2014 Aug 25. Abstract

More Publications