Figure 4 Search Clinical Trials Find a Researcher Order a Test Figure 2. Genetics of innate immunity. Inbred strains of mice, both wild type for TLR4 and with mutations in TLR4, show a wide range of responses to inhaled LPS challenge, suggesting that genes other than TLR4 are important in the murine response to LPS. Adapted from Lorenz. Am J Physiol 2001; 281:L1106.