Kappler Marrack Research Lab

Recent Publications

Bai X, Stitzel JA, Bai A, Zambrano CA, Phillips M, Marrack P and Chan ED. Nicotine impairs macrophage control of tuberculosis. Am J Respir Cell Mol Biol. In press 2017.

Rubtsova K, Rubtsov AV, Thurman JM, Mennona JM, Kappler JW and Marrack P. B cells expressing the transcription factor T-bet drive lupus-like immunity. J. Clin, Invest. 127:1392-1404, 2017.  PMC 5373868.

Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M.  roinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes. Diabetes 66:722-734, 2017. PMC5319719.

Ranasinghe S, Lamothe PA, Soghoian DZ, Kazer SW, Cole MB, Shalek AK, Yosef N, Jones RB, Donaghey F, Nwonu C, Jani P, Clayton GM, Crawford F, White J, Montoya A, Power K, Allen TM, Streeck H, Kaufmann DE, Picker LJ, Kappler JW, Walker BD. Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. Immunity 45:917-930, 2016.  PMC5077698.

Noges LE, White J, Cambier JC, Kappler JW and Marrack P. Contamination of DNase preparations confounds analysis of the role of DNA in alum adjuvanted vaccines. J. Immunol. 197:1221-1230, 2016. PMC4974487.

Silberman D, Krovi SH, Tuttle KD, Crooks J, Reisdorph R, White J, Gross J, Matsuda JL, Gapin L, Marrack P and Kappler JW. Class II major histocompatibility complex mutant mice to study the germline bias of T cell antigen receptors. Proc. Natl. Acad. Sci USA 113:E5608-17, 2016.  PMC 5035841.

Rubtsova, K, Rubtsov, AV Halemano K, Sam LX, Kappler JW, Sanitago ML and Marrack P. T cell production of IFNg in response to TLR7/IL12 stimulates optimal B cell responses to viruses.  PLoS One 0166322, 2016. PMC 5120817.

Munson DJ, Egelston CA, Chiotti KE, Parra ZE, Bruno TC, Moore BL, Nakano TA, Simons DL, Jimenez G, Yim JH, Rozanov DV, Falta MT, Fontenot AP, Reynolds PR, Leach SM, Borges VF, Kappler JW, Spellman PT, Lee PP, Slansky JE. Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR. Proc. Natl. Acad. Sci. U.S.A. 113:8272-7, 2016.  PMC4961128.

Fontenot AP, Falta MT, Kappler JW, Dai S, McKee AS. Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J Immunol. 196:22-7, 2016.  PMC4685955.

Fontenot, A. P., Falta, M. T., Kappler, J. W., Dai, S. & McKee, A. S. Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J. Immunol. 196, 22–27 (2016).

Falta, M. T. et al. Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice. Mucosal Immunol 9, 218–228 (2016).

Jin, N. et al. N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes. Proc. Natl. Acad. Sci. U.S.A. 112, 13318–13323 (2015).

Rubtsova, K., Rubtsov, A. V., Cancro, M. P. & Marrack, P. Age-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic Immunity. J. Immunol. 195, 1933–1937 (2015).

Rubtsov, A. V. et al. CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs. J. Immunol. 195, 71–79 (2015).

Atif, S. M. et al. Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts. J. Immunol. 195, 46–50 (2015).

Rubtsova, K., Marrack, P. & Rubtsov, A. V. TLR7, IFNgamma, and T-bet: their roles in the development of ABCs in female-biased autoimmunity. Cell Immunol 294, 80–83 (2015).

Nakayama, M. et al. Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects. Proc. Natl. Acad. Sci. U.S.A. 112, 4429–4434 (2015).

Liu, H. et al. A Rapid Method to Characterize Mouse IgG Antibodies and Isolate Native Antigen Binding IgG B Cell Hybridomas. PLoS One 10, e0136613 (2015).

Ito, Y. et al. Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease. Science 346, 363–368 (2014).

Yang, J. et al. Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes. Proc. Natl. Acad. Sci. U.S.A. 111, 14840–14845 (2014).

Clayton, G. et al. Structural Basis of Chronic Beryllium Disease: Linking Allergic Hypersensitivity and Autoimmunity. Cell 158, 132–142 (2014).

Clambey, E. T., Davenport, B., Kappler, J. W., Marrack, P. & Homann, D. Molecules in medicine mini review: the alphabeta T cell receptor. J Mol Med (Berl) 92, 735–741 (2014).

Mack, D. G. et al. Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease. Proc. Natl. Acad. Sci. U.S.A. 111, 8553–8558 (2014).

David, A. et al. Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation. Proc. Natl. Acad. Sci. U.S.A. 111, 7735–7740 (2014).

Bedel, R. et al. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc. Natl. Acad. Sci. U.S.A. 111, E119–28 (2014).

Rubtsova, K., Rubtsov, A. V., van Dyk, L. F., Kappler, J. W. & Marrack, P. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc. Natl. Acad. Sci. U.S.A. 110, E3216–24 (2013).

Falta, M. T. et al. Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease. J. Exp. Med. 210, 1403–1418 (2013).

McKee, A. S. et al. Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 110, E1122–31 (2013).

Rubtsov, A. V., Rubtsova, K., Kappler, J. W. & Marrack, P. TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice. Immunol Res 55, 210–216 (2013).

Collins, B. et al. Ikaros promotes rearrangement of TCR alpha genes in an Ikaros null thymoma cell line. Eur J Immunol 43, 521–532 (2013).

Clambey, E. T. et al. The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells. PLoS One 8, e57435 (2013).

Macleod, M. K. L. et al. Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence. PLoS One 8, e61775 (2013).

Yin, L., Scott-Browne, J., Kappler, J. W., Gapin, L. & Marrack, P. T cells and their eons-old obsession with MHC. Immunol Rev 250, 49–60 (2012).

Yin, L., Crawford, F., Marrack, P., Kappler, J. W. & Dai, S. T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Proc. Natl. Acad. Sci. U.S.A. 109, 18517–18522 (2012).

Marrack, P. & Kappler, J. W. Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases? Cold Spring Harb Perspect Med 2, a007765 (2012).

Garcia, K. C. et al. A closer look at TCR germline recognition. Immunity 36, 887–888 (2012).