Kappler Marrack Research Lab

Recent Publications

Fontenot, A. P., Falta, M. T., Kappler, J. W., Dai, S. & McKee, A. S. Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J. Immunol. 196, 22–27 (2016).

Falta, M. T. et al. Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice. Mucosal Immunol 9, 218–228 (2016).

Jin, N. et al. N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes. Proc. Natl. Acad. Sci. U.S.A. 112, 13318–13323 (2015).

Rubtsova, K., Rubtsov, A. V., Cancro, M. P. & Marrack, P. Age-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic Immunity. J. Immunol. 195, 1933–1937 (2015).

Rubtsov, A. V. et al. CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs. J. Immunol. 195, 71–79 (2015).

Atif, S. M. et al. Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts. J. Immunol. 195, 46–50 (2015).

Rubtsova, K., Marrack, P. & Rubtsov, A. V. TLR7, IFNgamma, and T-bet: their roles in the development of ABCs in female-biased autoimmunity. Cell Immunol 294, 80–83 (2015).

Nakayama, M. et al. Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects. Proc. Natl. Acad. Sci. U.S.A. 112, 4429–4434 (2015).

Liu, H. et al. A Rapid Method to Characterize Mouse IgG Antibodies and Isolate Native Antigen Binding IgG B Cell Hybridomas. PLoS One 10, e0136613 (2015).

Ito, Y. et al. Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease. Science 346, 363–368 (2014).

Yang, J. et al. Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes. Proc. Natl. Acad. Sci. U.S.A. 111, 14840–14845 (2014).

Clayton, G. et al. Structural Basis of Chronic Beryllium Disease: Linking Allergic Hypersensitivity and Autoimmunity. Cell 158, 132–142 (2014).

Clambey, E. T., Davenport, B., Kappler, J. W., Marrack, P. & Homann, D. Molecules in medicine mini review: the alphabeta T cell receptor. J Mol Med (Berl) 92, 735–741 (2014).

Mack, D. G. et al. Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease. Proc. Natl. Acad. Sci. U.S.A. 111, 8553–8558 (2014).

David, A. et al. Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation. Proc. Natl. Acad. Sci. U.S.A. 111, 7735–7740 (2014).

Bedel, R. et al. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc. Natl. Acad. Sci. U.S.A. 111, E119–28 (2014).

Rubtsova, K., Rubtsov, A. V., van Dyk, L. F., Kappler, J. W. & Marrack, P. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc. Natl. Acad. Sci. U.S.A. 110, E3216–24 (2013).

Falta, M. T. et al. Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease. J. Exp. Med. 210, 1403–1418 (2013).

McKee, A. S. et al. Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 110, E1122–31 (2013).

Rubtsov, A. V., Rubtsova, K., Kappler, J. W. & Marrack, P. TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice. Immunol Res 55, 210–216 (2013).

Collins, B. et al. Ikaros promotes rearrangement of TCR alpha genes in an Ikaros null thymoma cell line. Eur J Immunol 43, 521–532 (2013).

Clambey, E. T. et al. The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells. PLoS One 8, e57435 (2013).

Macleod, M. K. L. et al. Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence. PLoS One 8, e61775 (2013).

Yin, L., Scott-Browne, J., Kappler, J. W., Gapin, L. & Marrack, P. T cells and their eons-old obsession with MHC. Immunol Rev 250, 49–60 (2012).

Yin, L., Crawford, F., Marrack, P., Kappler, J. W. & Dai, S. T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Proc. Natl. Acad. Sci. U.S.A. 109, 18517–18522 (2012).

Marrack, P. & Kappler, J. W. Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases? Cold Spring Harb Perspect Med 2, a007765 (2012).

Garcia, K. C. et al. A closer look at TCR germline recognition. Immunity 36, 887–888 (2012).