COPD Basic Research
Investigators at National Jewish Health conduct extensive basic research into the mechanisms involved in the development and resolution of emphysema and chronic bronchitis.
COPD Basic Research Areas of Interest
- Translational studies of COPD development mechanisms
- COPD genetic association studies
- GWAS for airflow limitation and emphysema
- COPD genomic studies
- Proteomics studies of COPD
- Metabolomic studies of COPD
- Biomarkers predictive of acute exacerbations and hospitalizations for COPD
- Novel drug therapy to reduce progression of COPD
COPD Animal Models
National Jewish investigators use several animal models to study aspects of the development and resolution of COPD based on well-characterized experimental endpoints that include airway inflammation and emphysema.
- Mouse tobacco smoke exposure model
- Rat tobacco smoke exposure model
- E-cigarette mouse exposure models
- Morphometric analysis of lung
- Genomics of lung disease
- Metabolomics of lung disease
- Proteomics of lung disease
- Systems biology with insights into COPD pathogenesis
COPD Cell Cultures
National Jewish investigators also have extensive expertise in the in vitro study of tobacco smoke. These studies involved assessment of exposure of either whole tobacco smoke or cigarette smoke extract. An extensive collection of primary peripheral blood and airway cells as well as banked lung tissue are available from COPD patients.