Sonia M. Leach
Assistant Professor
Director of Bioinformatics
Department of Biomedical Research
Office of Academic Affairs
Center for Genes, Environment and Health
  • 5280 Top Doctors 2016
  • Recognized as a 5280 Top Doctor
  • America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd.
  • Recognized in America’s Top Doctors — Castle Connolly, Inc.
  • Best Doctors in America® 2015 — Best Doctors, Inc.
  • Recognized in Best Doctors in America® — Best Doctors, Inc.
  • America’s Top Doctors 2016 — Castle Connolly Medical, Ltd.
  • image descriptionPrograms & Services
    Research AreasResearch Areas
    • Computational Biology
    • Genomic Data Integration
    • Genomics
    • Probabilistic Graphical Models
    • Proteomics, Metabolomics
    • Translational Research

    Special Interests

    Research Interests

    Dr. Leach's responsibilities at the Center for Genes, Environment and Health are to develop computational algorithms for the analysis and interpretation of genomic and proteomic datasets. She is particularly interested in methods which integrate diverse types of genomic data in order to explain high-throughput data results and prioritize those results for further follow-up studies.


    Brown University, PhD


    O'Connor BP, Danhorn T, De Arras L, Marcus RA, Farias-Hesson E, Leach SM, Alper S. Regulation of Toll-like receptor signaling by the SF3a mRNA splicing complex. PLoS Genetics 2015; 11(2):e1004932.

    Kim J, Vasu VT, Mishra R, Singleton KR, Yoo M, Leach SM, Farias-Hesson E, Mason RJ, Kang J, Ramamoorthy P, Kern JA, Heasley LE, Finigan JH, Tan AC. Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy. Bioinformatics 2014. May 7.

    De Arras L, Laws R, Leach SM, Pontis K, Freedman JH, Schwartz DA, Alper S (2013) Comparative Genomics RNAi Screen Identifies Eftud2 as a Novel Regulator of Innate Immunity. Genetics. 2013 Dec 20.

    Gabehart K, Correll KA, Yang J, Collins ML, Loader JE, Leach S, White CW, Dakhama A (2013) Transcriptome profiling of the newborn mouse lung response to acute ozone exposure. Toxicol Sci. 2013 Dec 12.

    Yang IV, Coldren CD, Leach SM, Seibold MA, Murphy E, Lin J, Rosen R, Neidermyer AJ, McKean DF, Groshong SD, Cool C, Cosgrove GP, Lynch DA, Brown KK, Schwarz MI, Fingerlin TE, Schwartz DA. (2013) Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis. Thorax. 2013 Jun 19.

    Academic Affiliations

    Assistant Professor, Computational Bioscience Program, University of Colorado Denver

    Website Information

    Leach Lab Website

    Contact Information

    • Office: 303.270.2568
    • Fax: 303.270.2136
    • Email:



    • National Jewish Health Main Campus
      1400 Jackson St.
      Denver, CO 80206

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