Sonia M. Leach
Assistant Professor
Director of Bioinformatics
Department of Biomedical Research
Office of Academic Affairs
Center for Genes, Environment and Health
image descriptionPrograms & Services
Research AreasResearch Areas
  • Computational Biology
  • Genomic Data Integration
  • Genomics
  • Probabilistic Graphical Models
  • Proteomics, Metabolomics
  • Translational Research

Special Interests

Research Interests

Dr. Leach's responsibilities at the Center for Genes, Environment and Health are to develop computational algorithms for the analysis and interpretation of genomic and proteomic datasets. She is particularly interested in methods which integrate diverse types of genomic data in order to explain high-throughput data results and prioritize those results for further follow-up studies.


Brown University, PhD


O'Connor BP, Danhorn T, De Arras L, Marcus RA, Farias-Hesson E, Leach SM, Alper S. Regulation of Toll-like receptor signaling by the SF3a mRNA splicing complex. PLoS Genetics 2015; 11(2):e1004932.

Kim J, Vasu VT, Mishra R, Singleton KR, Yoo M, Leach SM, Farias-Hesson E, Mason RJ, Kang J, Ramamoorthy P, Kern JA, Heasley LE, Finigan JH, Tan AC. Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy. Bioinformatics 2014. May 7.

De Arras L, Laws R, Leach SM, Pontis K, Freedman JH, Schwartz DA, Alper S (2013) Comparative Genomics RNAi Screen Identifies Eftud2 as a Novel Regulator of Innate Immunity. Genetics. 2013 Dec 20.

Gabehart K, Correll KA, Yang J, Collins ML, Loader JE, Leach S, White CW, Dakhama A (2013) Transcriptome profiling of the newborn mouse lung response to acute ozone exposure. Toxicol Sci. 2013 Dec 12.

Yang IV, Coldren CD, Leach SM, Seibold MA, Murphy E, Lin J, Rosen R, Neidermyer AJ, McKean DF, Groshong SD, Cool C, Cosgrove GP, Lynch DA, Brown KK, Schwarz MI, Fingerlin TE, Schwartz DA. (2013) Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis. Thorax. 2013 Jun 19.

Academic Affiliations

Assistant Professor, Computational Bioscience Program, University of Colorado Denver

Website Information

Leach Lab Website

Contact Information

  • Office: 303.270.2568
  • Fax: 303.270.2136
  • Email:



  • National Jewish Health Main Campus
    1400 Jackson St.
    Denver, CO 80206

Patient Ratings

The Patient Rating score is an average of all responses to care provider related questions on our independent rating system, the Press Ganey Patient Satisfaction Survey.

Responses are measured on a scale of 1 to 5, with 5 being the best score. Learn more about our patient satisfaction survey.


Comments are collected in our Press Ganey Patient Satisfaction Surveys. Patients are de-identified to protect confidentiality and patient privacy. Learn more about our patient satisfaction survey.