Philippa Marrack, PhD, FRS

Philippa Marrack
Chair, Biomedical Research Department
Distinguished Professor
  • 5280 Top Doctors 2016
  • Recognized as a 5280 Top Doctor
  • America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd.
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  • Best Doctors in America® 2015 — Best Doctors, Inc.
  • Recognized in Best Doctors in America® — Best Doctors, Inc.
  • America’s Top Doctors 2016 — Castle Connolly Medical, Ltd.
  • Research AreasResearch Areas
    • Basic Immunology

    Special Interests

    Research Interests

    We study T cells. T cells are amongst the cells which recognize that an infection is occurring in the body. They accomplish this in an unexpected way, by reacting with fragments of the infection bound to special proteins of the body, the MHC proteins. We are trying to find out how T cells learn to react in this way. We are also interested in the ways in which T cells are prevented from attacking MHC proteins bound to fragments of their own host. In most people such attack is efficiently avoided. However, in some individuals T cells do react in this way, and this event causes autoimmune diseases such as rheumatoid arthritis and juvenile diabetes. On the other side of the coin, the vaccines work by stimulating the ability of T cells to attack invaders. We study how vaccines accomplish this, with the hope that this understanding will help us design better vaccines.

    Education

    Education
    Cambridge University, England, PhD
    Cambridge University, England, BA, MA
    Fellowship
    University of California (San Diego, CA), Postdoctoral fellowship with Dr. Richard Dutton

    Awards & Recognition

    2015: National Women’s Hall of Fame
    2015: Wolf Prize in Medicine, Wolf Foundation
    2004: National Jewish Health Abraham J. Kauvar Presidential Award
    2004: University of Colorado Health Sciences Center, School of Medicine, Mentoring Award
    2004: L’Oreal UNESCO for Women in Science Award
    2003: Faculty Ambassador Award, National Jewish Health
    2000: Lifetime Achievemant Award, American Association of Immunologists
    2001: Irvington Institute Scientific Leadership Award in Immunology
    1999: Interscience Conference on Antimicrobial Agents and Chemotherapy Award
    1999: University of Chicago, Howard Taylor Ricketts Prize
    1998: The Rabbi Shai Schacknai Memorial Prize
    1996: Honorary Doctorate of Sciences, Macalester College
    1995: Dickson Prize in Medicine, University of Pittsburgh
    1995: Behring-Heidelberger Lecture Award
    1995: FASEB Excellence in Science Award
    1995: The Louisa Gross Horwitz Prize-Columbia University
    1993: The Paul Ehrlich and Ludwig Darmstädter Prize, Germany
    1993: Cancer Research Institute's 1993 William B. Coley Award for Distinguished Research in Fundamental Immunology
    1992: The Ernst W. Bertner Memorial Award, MD Anderson Cancer Center 1991: Honorary Doctorate of Sciences, University of Rochester

    Professional Memberships

    British Society of Immunology
    American Association of Immunologists
    The Royal Society
    The National Academy of Sciences USA
    American Academy of Arts and Sciences

    Publications

    Scott-Browne, J.P., White, J., Kappler, J.W., Gapin, L. and Marrack, P. Germline-encoded amino acids in the alpha beta T cell receptor control thymic selection. Nature in press, 2009.

    Desbien, A., Kappler, J. and Marrack, P. The Epstein Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim. Proc. Natl. Acad. Sci. USA, in press, 2009. PMC 2657086.

    Marrack, P., McKee, A.S. and Munks, M.W. Towards an understanding of the adjuvant action of aluminium. Nature Reviews Immunology 9;287-293, 2009.

    McKee, A.S., MacLeod, M., White, J., Crawford, F., Kappler, J.W. and Marrack, P. Gr1/IL-4 producing innate cells are induced in response to TH2 stimuli and suppress TH1-dependent antibody responses. Int. Immunol. 20:659-669, 2008. 367.

    MacLeod, M., McKee, A., Crawford, F., White, J., Kappler, J. and Marrack, P. CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proc. Natl. Acad. Sci. USA 105:14521-6. 2008. PMCID: PMC2533680

    Academic Affiliations

    Distinguished Professor, University of Colorado Denver
    Professor in the Department of Immunology & Microbiology and the Depts. of Biochemistry and Molecular Biology and Medicine, University of Colorado Denver

    Website Information

    Kappler Marrack Lab

    Contact Information

    • Office: 303.398.1322
    • Fax: 303.270.2166
    • Email: marrackp@njhealth.org

     

    Locations

    • National Jewish Health Main Campus
      1400 Jackson St.
      Denver, CO 80206

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