Proteomics, Metabolomics, Mass Spectrometry. Dr. Reisdorph's research is designed to integrate clinical proteomics, metabolomics, and bioinformatics in order to develop and customize clinically relevant methodologies to diagnose or monitor disease states. Results from these studies will also significantly enhance the knowledge of the biochemical mechanisms of diseases. In addition, Dr’s Reisdorph’s facility will specialize in post-translational modification analysis as well as the identification of differentially regulated proteins from a variety of sources including cell extracts, biofluids, and tissue samples. Dr. Reisdorph uses a variety of techniques in her work, including two-dimensional gel electrophoresis, DiGE, tandem mass spectrometry, and quantitative labeling and non-labeling strategies. Dr. Reisdorph organizes proteomics hands-on workshops and web-based courses through National Jewish Health and the University of Colorado at Denver and Health Science Center. Since 2005, Dr. Reisdorph and her team have instructed almost a dozen 3-4 day workshops, for a total of over 120 individuals, who come from a variety of backgrounds. Dr. Reisdorph is currently expanding her training program to include additional hands on courses, such as quantitative proteomics, and distance-learning courses, such as database searching.
Armstrong, M., Liu, A., Harbeck, R., Reisdorph, R., Rabinovitch, N., Reisdorph, N. (2009) Leukotriene-E4 in human urine: Comparison of on-line purification and liquid chromatography-tandem mass spectrometry to affinity purification followed by enzyme immunoassay. J Chromatography B 877:3169-3174.
Broccardo, C., Mahaffey, S., Strand, M., Reisdorph, N., Leung, D. (2009) Peeling Off the Layers: Skin Taping and a Novel Proteomics Approach to Study Atopic Dermatitis. J Allergy Clinical Immunology ePub ahead of print (DOI 10.1016)
Reisdorph, N., Reisdorph, R., Bowler, R., Broccardo, C. (2009) Proteomics Methods and Applications for the Practicing Clinician. Annals of Allergy, Asthma, and Immunology. 102:523-529.
Bowler, R., Reisdorph, N., Reisdorph, R., Abraham E. (2009) Alterations in BALF proteome with LPS and activated protein C. BMC Pulmonary Medicine 9:20
Jin, L., Jonscher, K., Waterman, P., Reisdorph, N., Cambier, J. (2008) MPYS, a novel MHC class I-associated tetrapanner required for transduction of apoptotic signals in B cells. Mol Cell Biol. 16:5014-26.