Laurel L. Lenz Jr
Associate Professor
  • 5280 Top Doctors 2016
  • Recognized as a 5280 Top Doctor
  • America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd.
  • Recognized in America’s Top Doctors — Castle Connolly, Inc.
  • Best Doctors in America® 2015 — Best Doctors, Inc.
  • Recognized in Best Doctors in America® — Best Doctors, Inc.
  • America’s Top Doctors 2016 — Castle Connolly Medical, Ltd.
  • Research AreasResearch Areas
    • Basic Immunology
    • Cellular and Molecular Biology
    • Immunobiology
    • Infectious Diseases
    • Inflammation
    • Innate Immunity
    • Interferons and Cytokines
    • Molecular Immunology
    • Myeloid Cells
    • NK cells

    Special Interests

    Research Interests

    We study mechanisms of immune subversion and immune regulation during bacterial infections and other disease settings. We dissect strategies that microbes have evolved to thwart or manipulate immune responses and work to define host immune regulatory circuits that are manipulated by pathogens. Our studies focus on innate immune responses during mucosal and systemic infections. We are actively pursuing translation of information from our studies towards improved therapies for infectious, inflammatory, cancerous, and other diseases.


    University of Washington, Seattle, PhD, Immumnology
    Kansas State University, BA, Microbiology
    University of California - Berkeley, Department of Molecular and Cell Biology

    Awards & Recognition

    Editorial Boards: Frontiers in NK cell Biology, Frontiers in Microbial Immunology, PLoS ONE, Journal of Immunology.

    Professional Memberships

    American Association of Immunologists
    Society for Natural Immunity
    Society for Mucosal Immunology
    Cytokine and Interferon Society


    Rayamajhi M, Humann J, Penheiter K, Andreasen K and Lenz LL.  2010.  Induction of IFNαβ enables Listeria monocytogenes to suppress macrophage activation by IFNγ. J. Exp. Med. 207:327-37.

    Humann J and Lenz LL.  2010.  Activation of naïve NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. J. Immunol. 184:5172-8.

    A LysM and SH3-Domain Containing Region of the Listeria monocytogenes p60 Protein Stimulates Accessory Cells to Promote Activation of Host NK Cells. Schmidt RL, Filak HC, Lemon JD, Potter TA, Lenz LL. PLoS Pathog. 2011. Nov;7(11):e1002368.

    Rayamajhi M, Delgado C, Condon TV, Riches DW, and Lenz LL. 2012. “Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax” Mucosal Immunol. in press

    Cole C, Thomas S, Filak H, Henson PM, and Lenz LL. 2012. “Nitric oxide increases susceptibility of toll-like receptor-activated macrophages to spreading Listeria monocytogenes.” Immunity in press.

    Academic Affiliations

    Associate Professor, Departments of Immunology and Microbiology, University of Colorado Denver
    Training Faculty, Biomedical Sciences Program, Reproductive Sciences Program, University of Colorado Denver
    Member, University of Colorado Cancer Center, University of Colorado Denver

    Teaching & Professional Positions

    No current positions.


    Industry Relationships & Collaborations

    National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations.

    Website Information

    Department of Immunology and Microbiology, University of Colorado School of Medicine 

    Contact Information

    • Office: 303.398.1767
    • Fax: 303.398.1396
    • Email:



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      1400 Jackson St.
      Denver, CO 80206

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