John W. Kappler
Department of Biomedical Research
  • 5280 Top Doctors 2016
  • Recognized as a 5280 Top Doctor
  • America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd.
  • Recognized in America’s Top Doctors — Castle Connolly, Inc.
  • Best Doctors in America® 2015 — Best Doctors, Inc.
  • Recognized in Best Doctors in America® — Best Doctors, Inc.
  • America’s Top Doctors 2016 — Castle Connolly Medical, Ltd.
  • Research AreasResearch Areas


    Brandeis University, PhD, Biochemistry
    Lehigh University, BA, Chemistry
    University of California at San Diego, Department of Biology,

    Awards & Recognition

    2015: Wolf Prize in Medicine, Wolf Foundation
    Louisa Gross Horwitz Prize, Columbia University
    Bonfils-Stanton Foundation Award in Science and Medicine
    National Jewish Health Lifetime Achievement Award
    Advisory Editor, Journal of Immunology
    Ad hoc member NIH Transplantation Biology and Immunology Committee
    Damon Runyon Foundation for Cancer Research Fellowship Review Committee

    Professional Memberships

    American Association of Immunologists
    American Association for the Advancement of Science
    National Academy of Sciences
    Institute of Medicine of the NAS


    Yang B, Gay DL, Macleod MK, Cao X, Hala T, Sweezer EM, Kappler J, Marrack P, Oliver PM. Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol. 2008 Dec;9(12):1356-63.

    MacLeod MK, McKee A, Crawford F, White J, Kappler J, Marrack P. CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14521-6.

    Clambey ET, White J, Kappler JW, Marrack P. Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12997-3002.

    Dai S, Crawford F, Marrack P, Kappler JW. The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11893-7.

    Marrack P, Rubtsova K, Scott-Browne J, Kappler JW. T cell receptor specificity for major histocompatibility complex proteins. Curr Opin Immunol. 2008 Apr;20(2):203-7.

    Academic Affiliations

    1993-Present: Distinguished Professor, University of Colorado Denver

    Teaching & Professional Positions

    Senior Faculty, Integrated Dept. of Immunology, National Jewish Health and University of Colorado Denver

    Website Information

    Kappler Lab

    Contact Information

    • Office: 303.398.1322
    • Fax: 303.270.2166
    • Email:



    • National Jewish Health Main Campus
      1400 Jackson St.
      Denver, CO 80206

    Patient Ratings

    The Patient Rating score is an average of all responses to care provider related questions on our independent rating system, the Press Ganey Patient Satisfaction Survey.

    Responses are measured on a scale of 1 to 5, with 5 being the best score. Learn more about our patient satisfaction survey.


    Comments are collected in our Press Ganey Patient Satisfaction Surveys. Patients are de-identified to protect confidentiality and patient privacy. Learn more about our patient satisfaction survey.