John C. Cambier
Department of Biomedical Research
  • 5280 Top Doctors 2016
  • Recognized as a 5280 Top Doctor
  • America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd.
  • Recognized in America’s Top Doctors — Castle Connolly, Inc.
  • Best Doctors in America® 2015 — Best Doctors, Inc.
  • Recognized in Best Doctors in America® — Best Doctors, Inc.
  • America’s Top Doctors 2016 — Castle Connolly Medical, Ltd.
  • Research AreasResearch Areas

    Special Interests

    Research Interests

    Autoimmunity, immunodeficiency, allergy Transmembrane signal transduction in immune adaptation to environment queues and pathogens. Immunologic tolerance, regulation of the immune response and immunosenescence.


    University of Iowa, PhD
    University of Iowa, MS
    SW Missouri State, BS
    University of Texas, Southwestern Health Sciences Center,

    Awards & Recognition

    Ida and Cecil Green Chair

    ISI Most Highly Cited

    Editorial Boards: Immunity, Immunology, Immunologic Reviews, J. Clinical Immunology, BMC Immunology, Current Opinion in Immunology

    Professional Memberships

    American Association of Immunology


    Decote-Ricardo D, Chagas KKF, Rocha JDB, Lima MEF, Redner P, Lopes UG, Cambier JC, Arruda-Hinds, L, Pecanha LMT. 2009. Modulation of in vitro murine B-lymphocyte response by curcumin and its synthetic analogues. Phytomedicine Oct; 16(10):982-8. PMID: 19303754

    O’Neill S, Veselits M, Zhang M, Labno C, Cao Y, Finnegan A, Uccellini M, Alegre M, Cambier JC, Clark M. 2009. Endocytic sequestration of the B Cell Antigen Receptor and Toll-like Receptor 9 in Anergic Cells. Proc Natl Acad Sci U.S.A Apr 14;106(15):6262-7. PMID: 19332776

    Jackson L, Cady CT , Cambier JC. 2009. TLR4-mediated signaling induces MMP9-dependent cleavage of B cell surface CD23. J Immunol Aug 15; 183(4):2585-92. PMID: 19635918

    Getahun A, O’Neill SK, Cambier JC. 2009. Establishing anergy as a bona fide in vivo mechanism of B cell tolerance. J Immunol. Nov 1;183(9):5439-41. PMID: 19843930

    Cady CT, Powell MS, Harbeck RJ, Giclas PC, Murphy JR, Katial RK, Weber RW, Hogarth PM, Johnson S, Bonvini E, Koenig S, Cambier JC. 2009. IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both Fc(gamma)RIIA and Fc(gamma)RIIB. Immunol Lett. Dec 14. PMID: 20004689

    Academic Affiliations

    Professor and Chair, Department of Immunology and Microbiology, University of Colorado School of Medicine

    Teaching & Professional Positions

    No current positions.


    Industry Relationships & Collaborations

    National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations.

    Contact Information

    • Office: 303.398.1325
    • Fax: 303.270.2325
    • Email:



    • National Jewish Health Main Campus
      1400 Jackson St.
      Denver, CO 80206

    Patient Ratings

    The Patient Rating score is an average of all responses to care provider related questions on our independent rating system, the Press Ganey Patient Satisfaction Survey.

    Responses are measured on a scale of 1 to 5, with 5 being the best score. Learn more about our patient satisfaction survey.


    Comments are collected in our Press Ganey Patient Satisfaction Surveys. Patients are de-identified to protect confidentiality and patient privacy. Learn more about our patient satisfaction survey.