Anne-Laure Perraud
Associate Professor
Department of Biomedical Research
  • 5280 Top Doctors 2016
  • Recognized as a 5280 Top Doctor
  • America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd.
  • Recognized in America’s Top Doctors — Castle Connolly, Inc.
  • Best Doctors in America® 2015 — Best Doctors, Inc.
  • Recognized in Best Doctors in America® — Best Doctors, Inc.
  • America’s Top Doctors 2016 — Castle Connolly Medical, Ltd.
  • Special Interests

    Research Interests

    Ion homeostasis regulation in immune cells.


    Kansai Medical University (Osaka, Japan), Dept. of Molecular Genetics, Guest scientist in Prof. Tomohiro Kurosaki''s research
    University of Würzburg, Germany, PhD
    University of Marburg, Germany, MS (Diplom)
    University of Bonn, Germany, BA (Vordiplom)
    University of Washington, Dept. of Pediatrics and Immunology, Senior Post-Doctoral Fellow
    Harvard Medical School / Beth-Israel Hospital, Dept. of Pathology, Post-Doctoral Fellow


    Perraud A.-L., Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM.: Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels, J Biol Chem 280: 6138-6148, 2005.

    Schmitz C. *, Perraud A.-L. *, Johnson C. O., Inabe K., Smith M. K., Penner R., Kurosaki T., Fleig A., Scharenberg A. M.: Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7, Cell 114(2):191-200, 2003.

    Perraud A.-L., Shen B., Dunn C. A., Rippe K., Smith M. K., Bessman M. J., Stoddard B. L., Scharenberg, A. M.: NUDT9, a member of the nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase, J Biol Chem 278(3):1794-801, 2003.

    Launay P. *, Fleig A. *, Perraud A.-L., Scharenberg, A. M., Penner R., Kinet J.-P.: TRPM4 Is a Ca(2+)-Activated Nonselective Cation Channel Mediating Cell Membrane Depolarization, Cell 109(3): 397-407, 2002.

    Perraud A.-L.*, Fleig A.*, Dunn C. A.*, Bagley L. A., Launay P., Schmitz C., Stokes A., Zhu Q., Bessman M. J., Penner R., Kinet J.-P., and Scharenberg A. M.: ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology, Nature 411(6837): 595-599, 2001.

    Contact Information

    • Office: 303.270.2078
    • Fax: 303.270.2325
    • Email:



    • National Jewish Health Main Campus
      1400 Jackson St.
      Denver, CO 80206

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