NIH RO1 ES017582-01
Targeting Oxidative Stress in Chronic Beryllium Disease
P.I. Brian J. Day
Total Award Period: 7/01/09 – 6/30/14
Goals: To (1) examine the effect of beryllium on APC antioxidant status and oxidative response; (2) examine the effect of altered antioxidant status on antigen presentation by APC and T cell activation responses to beryllium; (3) examine the role of oxidative stress on antigen presentation by APC and T cell activation responses to beryllium.
NIH RO1 HL084469
Adaptive glutathione responses to cigarette smoke in COPD
P.I. Brian J. Day
Total Award Period: 12/1/07 – 11/31/11
Goals: The overall goal of this application is to determine the role of glutathione (GSH) adaptive responses to cigarette smoke which is a major risk factor in chronic obstructive pulmonary disease (COPD). The specific aims are to: 1) examine mechanism(s) responsible for GSH adaptive responses stimulated by cigarette smoke; 2) examine whether defective extracellular GSH adaptive responses contributes to enhanced cigarette smoke-induced lung epithelial cell oxidation and injury upon exposure to extracellular oxidants; 3) Examine whether defective GSH transport sensitizes the lung to cigarette smoke-induced oxidative stress and inflammation.
NIH U54 ES015678-01 (CounterACT)
Novel Antioxidant Therapeutics for Sulfur Mustard Toxicity
Director Carl White
Project 2 Leader Brian J. Day
Total Award Period: 9/15/06 – 9/14/11
The overall goals of this project are to develop an effective treatment for mustard gas-induced injury. The specific aims are to: 1) determine the efficacy of catalytic antioxidants in rat and human models of CEES-induced lung injury; 2) determine the efficacy of catalytic antioxidants in mouse and human models of CEES-induced dermal injury; 3) develop and characterize a new class of catalytic antioxidants, the linear tetrapyrroles.