The Seibold Lab is focused on identifying genetic determinants and biomarkers of complex lung diseases, including asthma and pulmonary fibrosis. Many of the genetic variants that influence development and severity of these lung diseases do so by altering molecular functions in specific lung cell types. His lab is focused on identifying dysregulated molecular functions in patient lung cells, by Nex-Generation sequencing technologies. Using patient cohorts the genetic determinants of these molecular changes are then mapped. The lab is also editing the genome of these lung cells to allow detailed mechanistic studies of disease variants and better understanding of how these genetic changes increase risk of disease development.
The Seibold Lab is currently seeking students and post-doctoral fellows to be part of a collaborative team working to identify genetic determinants of complex lung diseases through the use of genetic epidemiology and molecular genetics.
- Nasal Airway Epithelia Expression Genetics and Epigenetics in Puerto Rican Asthmatics.
- Functional characterization of an IPF genetic risk variant.
- Genomic editing of primary lung cells.
- Genetics of expression in asthmatic bronchial epithelium
Dr. Max A. Seibold
A common MUC5B promoter polymorphism and pulmonary fibrosis. Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, Loyd JE, Fingerlin TE, Zhang W, Gudmundsson G, Groshong SD, Evans CM, Garantziotis S, Adler KB, Dickey BF, du Bois RM, Yang IV, Herron A, Kervitsky D, Talbert JL, Markin C, Park J, Crews AL, Slifer SH, Auerbach S, Roy MG, Lin J, Hennessy CE, Schwarz MI, Schwartz DA.
N Engl J Med. 2011 Apr 21;364(16):1503-12.