This information has been reviewed and approved by Lindsay Sense, RN, BSN, CMSRN (March 2022).
The CDC has advised that, upon receiving the primary doses of one of the approved vaccines, people should also get a booster shot after a specific interval. This is due to the effectiveness of the vaccines waning over time. People who are at-risk for severe infection, such as the immunocompromised, are especially encouraged to get an additional shot. You can read more about booster recommendation details here.
All of these COVID-19 vaccines will protect you, but here’s a side-by-side comparison. Remember to talk with your doctor if you have concerns about getting the vaccine.
Disclaimer: A direct comparison of effectiveness between the Pfizer and Moderna vaccines vs. the other vaccines
can’t be made, as COVID-19 was not as prevalent in the mRNA trials, and the variants had not developed. * EUA was paused April 13, 2021 and amended April 23, 2021 to include risk of rare blood clot in women under age 50.
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The information on our website is medically reviewed and accurate at the time of publication. Due to the changing nature of the COVID-19 pandemic, information may have since changed. CDC.gov and your state’s health department may offer additional guidance.