Reviewed by Barbara L. Goldstein, MD, MMSc

Because undifferentiated connective tissue (UCTD) disease can affect so many different parts of the body as an autoimmune disease, UCTD often has many symptoms.

Common symptoms of undifferentiated connective tissue disease include:

  • Weight loss

  • Fatigue

  • Low-grade fevers

  • Rash

  • Joint pain

  • Joint swelling

  • Color changes of hands and feet with cold exposure (known as Raynaud's disease)

  • Dryness of the eyes

  • Dryness of the mouth

  • Lymph node swelling

  • Muscle weakness

  • Muscle pains

  • Difficulty swallowing

  • Heartburn

  • Cough

  • Shortness of breath

  • Chest pain

Clinical Trials