Advanced Diagnostic Laboratories

Performed

Performed seven days a week.

Methodology

Line probe assay

Reported

Reports available within 24 to 48 hours

Lab Department

Mycobacteriology Lab (TB)

Synonyms

NTM-DR, NTMDR

Ordering Recommendations

• An AFB positive culture is from a patient without a history of NTM, tuberculosis is first ruled out.
• If negative, or the AFB positive culture is from a patient with a history of NTM, the NTM-DR line probe assay is performed

Related Tests

AFB3, AFB4, NTM3, NTM4, NTM5, NTM6, NTM9, NTM10

Reference Interval

N/A See Interpretive Data

Interpretive Data

Identification to the species and subspecies level where appropriate is performed using GenoType NTM-DR line probe assay (Hain Lifescience).    
 
            erm(41):
A thymine has been detected at position 28 (T28) of the erm(41) gene.
INDUCIBLE MACROLIDE RESISTANCE IS PREDICTED.
 
A cytosine has been detected at position 28 (C28) of the erm(41) gene.
THIS SUGGESTS SUSCEPTIBILITY TO MACROLIDES.
 
            rrl:
No mutations are present at rrl.
THIS SUGGESTS SUSCEPTIBILITY TO MACROLIDES.
 
A specific mutation is present at rrl and its sequence is identified.
MACROLIDE RESISTANCE IS PREDICTED.
 
A mutation is present at rrl, but not one of the frequent mutations; the identity of the mutation is not given. It is likely to be associated with macrolide resistance, but one cannot rule out silent mutations or other mutations not conferring resistance.
 
Heteroresistance detected at the rrl locus. This suggests an isogenic mycobacterial population exhibiting a range of susceptibilities or a mixed population.
 
            rrs:
No mutations are present at rrs.
THIS SUGGESTS SUSCEPTIBILITY TO AMINOGLYCOSIDES.
 
A specific mutation is present at rrs and its sequence is identified.
AMINOGLYCOSIDE RESISTANCE IS PREDICTED.
 
A mutation is present at rrs, but not one of the frequent mutations; the identity of the mutation is not given. It is likely to be associated with aminoglycoside resistance, but one cannot rule out silent mutations or other mutations not conferring resistance.
Heteroresistance detected at the rrs locus. This suggests an isogenic mycobacterial population exhibiting a range of susceptibilities or a mixed population.
 

CPT Code

87798x2