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Home > Hyper IgE Syndrome Panel
Collect one green top (sodium or lithium heparin) tube and one purple top (EDTA tube).
Collect 10 mL of whole blood and two (2) foam-tipped buccal swabs prior to food or drink, or after thoroughly rinsing mouth with water.
Additionally, please send one normal control (heparin green top tube) from a healthy, unrelated individual.
Preferred Swab: Puritan cat. no. 25-1506 1PF available from Andwin Scientific at 951.674.5646 for distribution information.
Do not centrifuge! Keep at room temp (18-22°C).
Preferred volume: 10 mL green top tube; 5 mL purple top tube.
Minimum volume: 6 mL green top; 1 mL purple top
Frozen, clotted, hemolyzed or centrifuged specimens. Anticoagulants other than heparin. Specimens >24 hrs old.
Maintain and transport specimens at room temperature (18-22°C).
Ship specimens Priority Overnight via Fed Ex in container sufficiently insulated to avoid temperature extremes (<10°C and >37°C).
24 hours at room temperature (18-22°C)
Samples accepted Monday - Thursday, no later than noon on Thursday. Samples must arrive within 24 hours of collection.
Informed Consent is required prior to completing any of the following tests. Consent must be obtained by the provider and maintained in the patient medical record. Download and print an informed consent form here.
PCR amplification followed by bi-directional sequencing of the DNA binding and SH2 domains.
Lymphocyte stimulation followed by intra-cellular cytokine staining for IL-17
Immunology Lab - Functional Assay
TH17 (Hyper IgE Syndrome Panel);IL-17 (Hyper IgE Syndrome Panel);STAT3 (Hyper IgE Syndrome Panel)
See individual components
Mutations of the gene encoding STAT3 are associated with the Hyper IgE syndrome (HIES). Because development of TH17 cells is dependent on STAT3, patients with HIES may have depressed levels of TH17 cells, thereby resulting in a compromised ability to fight infections. Analysis of the percentage of circulating TH17 cells assists in the evaluation of HIES.
TH17: 86353, 88184, 88185
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Advanced Diagnostic Laboratories
1400 Jackson St
Denver, CO 80206
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