Stijn P. De Langhe, PhD

Stijn P. De Langhe
Associate Professor
Division of Cell Biology
Department of Pediatrics
Stijn P. De Langhe, PhD, is a researcher at National Jewish Health. Dr. Langhe is in the Division of Cell Biology and Department of Pediatrics.

Research AreasResearch Areas

Special Interests

Research Interests

Our group focuses on lung development, lung regeneration and lung stem cells. We are especially interested in how Wnt and FGF signaling pathways between stem cells and their niche control the differentiation, proliferation and maintenance of several mesenchymally and epithelial cell lineages.


Ghent University (Belgium)/Childrens Hospital Los Angeles, PhD, Biotechnology
Ghent University (Belgium), MS, Biotechnology/Biochemistry
Childrens Hospital Los Angeles/USC Keck School of Medicine,


De Langhe, S.P., Carraro, G., Tefft, D., Li, C., Xu, X., Chai, Y., Minoo, P., Hajihosseini, M.K., Drouin, J., Kaartinen, V., et al. (2008). Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS ONE 3, e1516.

De Langhe, S.P., Carraro, G., Warburton, D., Hajihosseini, M. K., and Bellusci, S. (2006). Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol 299, 52-62.

del Moral,P.M., De Langhe,S.P., Sala,F.G., Veltmaat,J.M., Tefft,D., Wang,K., Warburton,D., and Bellusci,S. (2006). Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Dev. Biol. 293, 77-89.

Mailleux,A.A., Kelly,R., Veltmaat,J.M., De Langhe,S.P., Zaffran,S., Thiery,J.P., and Bellusci,S. (2005). Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 132, 2157-2166.

De Langhe,S.P., Sala,F.G., del Moral,P.M., Fairbanks,T.J., Yamada,K.M., Warburton,D., Burns,R.C., and Bellusci,S. (2005). Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Dev. Biol. 277, 316-331.

Academic Affiliations

Assistant Professor, Department of Cell and Developmental Biology, University of Colorado Denver
Program in Cell Biology, Stem Cells and Developmental Biology, University of Colorado Denver

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