Scott Alper, PhD

Scott Alper
Assistant Professor
Department of Biomedical Research
Office of Academic Affairs
Center of Genes, Environment, and Health
Scott Alper, PhD, is a researcher at National Jewish Health. Dr. Alper is in the Center of Genes, Environment & Health and Office of Academic Affairs.

image descriptionPrograms & Services
Research AreasResearch Areas
  • Basic Immunology
  • Inflammation
  • Innate Immunity
  • Molecular Genetics

Special Interests

Diseases of the immune system such as sepsis, asthma, and atherosclerosis affect millions of people worldwide, and the incidence of many of these diseases is rising. My lab is focused on understanding the regulation of the innate immune response, particularly as it relates to the basis for such immunological diseases.


Harvard University, PhD


O’Connor, BP, Danhorn, T, De Arras, L, Flatley, BR, Marcus, RA, Farias-Hesson, E, Leach, SM and Alper, S. Regulation of Toll-like receptor signaling by the SF3a mRNA splicing complex. PLOS Genetics. 11(2):e1004932 (2015).

De Arras, L, Guthrie, BS and Alper, S. Using RNAi-interference to investigate the innate immune response in mouse macrophages. J. Vis. Exp. 93:e51306 (2014).

De Arras, L, Laws, R, Leach, S, Pontis, K, Freedman, JH, Schwartz, DA and Alper, S. Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity. Genetics 197: 485-496 (2014).

De Arras, L and Alper, S. Limiting of the innate immune response by SF3A-dependent control of MyD88 alternative mRNA splicing. PLOS Genetics 9(10):e1003855 (2013).

De Arras, L, Seng, A, Lackford, B, Keikhaee, MR, Bowerman, B, Freedman, JH, Schwartz, DA, Alper, S. An evolutionarily conserved innate immunity protein interaction network. J. Biol. Chem. 288: 1967-1978 (2013).

Academic Affiliations

Assistant Professor in the Department of Immunology and Microbiology, University of Colorado Denver

Website Information

Alper Laboratory

Contact Information

  • Office: 303.270.2659
  • Email:



  • National Jewish Health Main Campus
    1400 Jackson St.
    Denver, CO 80206

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