Magdalena Maria Gorska, MD, PhD

Magdalena Maria Gorska
Associate Professor
Department of Biomedical Research
Department of Medicine
Division of Allergy & Clinical Immunology
Magdalena Maria Gorska, MD, is a researcher at National Jewish Health. Dr. Gorska is in the Division of Allergy and Clinical Immunology.

Research AreasResearch Areas

Special Interests

Research Interests

Our laboratory studies the early life origins of asthma. A proportion of patients with asthma develops symptoms of their disease very early in life, sometimes in its first year. Genetic factors are contributory but fail to fully explain it. It is therefore increasingly recognized that development of early-life asthma is driven in substantial part by environmental exposures that are encountered by infants after birth and, indirectly, by exposures encountered by their mothers, in association with pregnancy and breastfeeding. Our laboratory is focused on maternal exposures, trying to delineate how they lead to asthma in offspring. The goals are to define maternal information that is gained and transmitted to offspring or lost and not transferred to offspring, elucidate routes of information transfer (placenta, breast milk, gametes), and delineate cells and pathways that are affected in offspring (cells and molecules of the immune system are of particular interest). The translational goals are to identify early-life biomarkers of predisposition to asthma in humans and define molecular targets for development of preventive drugs.  To accomplish these goals, the laboratory uses mouse models, blood samples from young children with high risk of developing asthma (API+), and a variety of immunological, signaling, transcriptomics and epigenetic approaches.

Education

Education
Medical University of Lodz, Poland, Habilitation degree
Medical University of Lodz, Poland, PhD
Medical University of Lodz, Poland, MD
Fellowship
National Jewish Health, Denver, CO, Postdoctoral Fellowship
University of Texas Medical Branch, Galveston, TX, Postdoctoral Fellowship

Awards & Recognition

2015-2019: 1R01HL122995-01A1
2015: National Jewish Health Outstanding Scientific Achievement Award
2014-2015: Biomedical Research Grant, American Lung Association
2012-2013: Faculty Development Investigator Award, Denver Children’s Environmental Health Center (NIEHS PO1 ES-018181 and EPA GAD 834515010)
2012: Invited speaker, Presidential Plenary Session, Annual Meeting of the American Academy of Asthma, Allergy and Immunology
2011-2014: KL2 Research Scholar Award, Colorado Clinical and Translational Sciences (NIH, KL2 TR001080)
2011-2013: Sheldon C. Siegel Investigator Grant Award, Asthma and Allergy Foundation of America
2011: Pilot grant, Basic Science Section of the Department of Medicine at National Jewish Health
2010-2011: Junior Faculty Pilot Award, Colorado Clinical and Translational Sciences Institute (NIH, UL1 TR001082)
2009: Invited speaker, Annual Meeting of the European Academy of Allergy and Clinical Immunology
2005-2006: Interest Section Award, American Academy of Asthma, Allergy and Immunology
2000-2002: James W. McLaughlin Award, University of Texas
1998-1999: Ministry of Health Scholarship, Poland
1996: European Union Tempus Scholarship, Nijmegen University Hospital, Holland
1993-1998: Lodz Medical University Scholarship, Poland
1992-1993: Polish Children Fund Scholarship, Poland
 

Professional Memberships

American Academy of Asthma, Allergy, and Immunology
American Association of Immunologists
Collegium Internationale Allergologicum

 

Publications

Gorska MM, Stafford SJ, Cen O, Sur S, and Alam R. Unc119, a Novel Activator of Lck/Fyn, is Essential for T Cell Activation. J. Exp. Med. 2004, 199:369-379. PMCID: PMC2211793

Gorska MM, Stafford S, Liang Q, Goplen N, Dharajiya N, Guo L, Sur S, Gaestel M, Alam R. MK2 controls the level of negative feedback in the NF-κB pathway and is essential for endothelial permeability and airway inflammation. J. Exp. Med. 2007, 204:1637-1652. PMCID: PMC2118652

Gorska MM, Alam R. A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia. Blood. 2012, 119:1399-1406. PMCID: PMC3286207

Manners S, Alam R, Schwartz DA, Gorska MM. A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust. J Allergy Clin Immunol. 2014, 134:63-72.e7. PMCID: PMC4065237. This article was highlighted in the JACI Editorial (Finkelman FD. Diesel exhaust particle exposure during pregnancy promotes development of asthma and atopy. J Allergy Clin Immunol. 2014, 134:73-4. PMID: 24835501)

Lenberg J, Qian Q, Sun Z, Alam R, Gorska MM. Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1β and IL-17A. J Allergy Clin Immunol. 2018, 141:1118-1122.e3. PMCID: PMC5844783.

Academic Affiliations

Associate Professor, Department of Medicine, Division of Allergy and Clinical Immunology, National Jewish Health

Teaching & Professional Positions

Associate Professor, Department of Medicine, Division of Allergy and Clinical Immunology, National Jewish Health

Conflicts of Interest

National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations.

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Contact Information

  • Office: 877.225.5654

 

Locations

  • National Jewish Health Main Campus
    1400 Jackson St.
    Denver, CO 80206

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