Lianghua Bin, MD, PhD Ask a Question Refer Patient Lianghua Bin, MD, is a pediatric allergist and immunologist at National Jewish Health. Dr. Bin is in the Division of Pediatric Allergy and Immunology. Assistant Professor Department of Pediatrics Division of Pediatric Allergy & Immunology 5280 Top Doctors 2020 Previously a 5280 Top Doctor America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd. Recognized in America’s Top Doctors — Castle Connolly, Inc. Best Doctors in America® 2019-2020 — Best Doctors, Inc. Recognized in Best Doctors in America® — Best Doctors, Inc. America’s Top Doctors 2020 — Castle Connolly Medical, Ltd. Email Profile Print Profile Overview Contact Info & Locations Programs & Services Division of Pediatric Allergy & Clinical Immunology Research Areas Anti-viral innate immunology Basic Immunology Cellular and Molecular Biology Eczema (Atopic Dermatitis) Overview Inflammation Skin Barrier Diseases Skin Biology Special Interests Research Interests My research focuses on the central topic in epidermis biology: the pathways that regulate stratified epidermis differentiation and the formation of a functional skin barrier. As the outermost tissue, the epidermis protects human body from various physical, chemical and microbial insults. A full functional skin barrier is paramount for human health. My research program will delineate the molecular mechanisms by which a normal functional epidermis barrier protects from environmental insults, how the environmental factors differentially shape keratinocytes’ epigenetic profile and transcriptome in individuals with different genetic background, and how epidermis and immune system reciprocally affect each other’s function. These studies will lead to better understand the pathogenesis of skin allergies, infections, inflammation, and tumors. Education Education 2000 Central South University (Hunan, China), PhD, Oncology 1995 Hunan Medical University (Hunan, China), MS, Surgical Pathology 1992 Hunan Medical University (Hunan, China), BS, Clinical Medicine Awards & Recognition 2008: Awarded the Eugene F. and Easton M. Crawford Pediatrics Research Fellowship Fund at National Jewish Health. 2001: Awarded the Priscilla Campbell Memorial Fellowship at National Jewish Medical and Research Center. Professional Memberships American Academy of Allergy Asthma & Immunology Publications Bin L, Kim BE, Hall CF, Leach SM, Leung DY (2011). Inhibition of transcription factor specific protein 1 alters the gene expression profile of keratinocytes leading to up-regulation of kellikrein-related peptidases and thymic stromal lymphopoietin. J Invest Dermatol. 131(11):2213-22. Bin L, Howell MD, Kim BE, Streib JE, Hall CF, Leung DY (2011). Specific protein 1 is pivotal in skin’s anti-viral response. J Allergy Clin Immunol. 127(2):430-438.e1-2 Menke C, Bin L, Thorburn J, Behbakht K, Ford HL, Thorburn A (2011). Distinct TRAIL resistant mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. Cancer Res. 71(5):1883-92. Bin L, Howell MD, Kim BE, Hall CF, Streib JE, Leung DY (2009). Inhibition of S100A11 gene expression impairs keratinocytes response against vaccinia virus through down-regulation of the IL-10 receptor 2 chain. J Allergy Clin Immunol. 124(2):270-7, 277.e1. Bin LH, Xu L, Shu HB (2003). TIRP: a novel TIR-domain containing adaptor protein involved in Toll/interleukin-1 receptor signaling. J Biol Chem 278(27):24526-24532. Ask a Question through Patient Portal Sign in to your My National Jewish Health patient portal account to communicate with your care team, manage appointments, and more. Create an Account Contact Information Office: 877.225.5654Fax: 303.398.1225 Locations National Jewish Health Main Campus 1400 Jackson St. Denver, CO 80206 Patient Ratings The Patient Rating score is an average of all responses to care provider related questions on our independent rating system, the Press Ganey Patient Satisfaction Survey. This survey is about the patient care experience and does not address crucial characteristics like medical decision-making, prescribing the best therapy, and patient outcomes. Responses are measured on a scale of 1 to 5, with 5 being the best score. Learn more about our patient satisfaction survey. Comments Comments are collected in our Press Ganey Patient Satisfaction Surveys. Patients are de-identified to protect confidentiality and patient privacy. Learn more about our patient satisfaction survey.