Kenneth C. Malcolm, PhD Ask a Question Refer Patient Kenneth C. Malcolm, PhD, is a researcher at National Jewish Health. Dr. Malcolm is in the Division of Pulmonary, Critical Care and Sleep Medicine. Assistant Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine 5280 Top Doctors 2022 Previously a 5280 Top Doctor America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd. Recognized in America’s Top Doctors — Castle Connolly, Inc. Best Doctors in America® 2019-2020 — Best Doctors, Inc. Recognized in Best Doctors in America® — Best Doctors, Inc. America’s Top Doctors 2020 — Castle Connolly Medical, Ltd. Email Profile Print Profile Overview Contact Info & Locations Programs & Services Department of Medicine Division of Pulmonary, Critical Care and Sleep Medicine (Adult) Research Areas Acute Lung Injury Cellular and Molecular Biology Cystic Fibrosis (CF) Gene Expression HIV/AIDS: Safety and Efficacy of Medications Infectious Diseases Inflammation Mycobacterium Abscessus and Neutrophils Neutrophil Biology Pseudomonas Type I Interferon Responses Viral Infections Special Interests Research Interests My research has focused on the signaling mechanisms of inflammatory and immune cells. Recently, my research is directed at the role of viral infections such as influenza to impact the pathogenesis of lung injury. Previous work has demonstrated the ability of a particular bacterial product, LPS, to drive the expression of specific anti-viral genes in neutrophils. The finding that neutrophils express anti-viral genes has instigated studies into the role of neutrophils in complications of respiratory viral infections. We use both cellular and animal models of viral infection and patients to assess the role of neutrophils in lung injury. Education Education 1993 University of Colorado Denver, Department of Pharmacology, PhD Publications Fessler, M.B., Arndt, P.G., Just, I., Nick, J.A., Malcolm, K.C., Worthen, G.S. (2007) Dual role for RhoA in suppression and induction of cytokines in the human neutrophil. Blood 109, 1248-1256. Malcolm K.C. and Worthen G.S. (2003) Lipopolysaccharide stimulates p38-dependent induction of anti-viral genes in neutrophils independently of paracrine factors. J. Biol. Chem. 278, 15693-15701. Avdi, N.A., Malcolm, K.C., Nick, J.A., Worthen, G.S. (2002) p38 mitogen-activated protein kinase-mediated regulation of the c-jun NH2 terminal kinase pathway in human neutrophils: a role for PP2A. J. Biol. Chem. 277, 40687-40696. Fessler M., Malcolm K.C., Duncan M., and Worthen G.S. (2002) An analysis of the lipopolysaccharide-stimulated human neutrophil using oligonucleotide microarrays and proteomics. J.Biol. Chem. 277, 31291-31302. Malcolm, K.C., Ross, A.H., Qui, R.-G., Symons, M., and Exton, J.H. (1994) Activation of rat liver phospholipase D by the small GTP-binding protein RhoA. J. Biol. Chem. 269, 25951-25954 Conflicts of Interest National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations. Ask a Question through Patient Portal Sign in to your My National Jewish Health patient portal account to communicate with your care team, manage appointments, and more. Create an Account Contact Information Office: 877.225.5654 Email: firstname.lastname@example.org Locations National Jewish Health Main Campus 1400 Jackson St. Denver, CO 80206 Patient Ratings The Patient Rating score is an average of all responses to care provider related questions on our independent rating system, the Press Ganey Patient Satisfaction Survey. This survey is about the patient care experience and does not address crucial characteristics like medical decision-making, prescribing the best therapy, and patient outcomes. Responses are measured on a scale of 1 to 5, with 5 being the best score. Learn more about our patient satisfaction survey. Comments Comments are collected in our Press Ganey Patient Satisfaction Surveys. Patients are de-identified to protect confidentiality and patient privacy. Learn more about our patient satisfaction survey.