Kenneth C. Malcolm, PhD

Special Interests

Research Interests

My research has focused on the signaling mechanisms of inflammatory and immune cells. Recently, my research is directed at the role of viral infections such as influenza to impact the pathogenesis of lung injury. Previous work has demonstrated the ability of a particular bacterial product, LPS, to drive the expression of specific anti-viral genes in neutrophils. The finding that neutrophils express anti-viral genes has instigated studies into the role of neutrophils in complications of respiratory viral infections. We use both cellular and animal models of viral infection and patients to assess the role of neutrophils in lung injury.

Publications

Fessler, M.B., Arndt, P.G., Just, I., Nick, J.A., Malcolm, K.C., Worthen, G.S. (2007) Dual role for RhoA in suppression and induction of cytokines in the human neutrophil. Blood 109, 1248-1256.

Malcolm K.C. and Worthen G.S. (2003) Lipopolysaccharide stimulates p38-dependent induction of anti-viral genes in neutrophils independently of paracrine factors. J. Biol. Chem. 278, 15693-15701.

Avdi, N.A., Malcolm, K.C., Nick, J.A., Worthen, G.S. (2002) p38 mitogen-activated protein kinase-mediated regulation of the c-jun NH2 terminal kinase pathway in human neutrophils: a role for PP2A. J. Biol. Chem. 277, 40687-40696.

Fessler M., Malcolm K.C., Duncan M., and Worthen G.S. (2002) An analysis of the lipopolysaccharide-stimulated human neutrophil using oligonucleotide microarrays and proteomics. J.Biol. Chem. 277, 31291-31302.

Malcolm, K.C., Ross, A.H., Qui, R.-G., Symons, M., and Exton, J.H. (1994) Activation of rat liver phospholipase D by the small GTP-binding protein RhoA. J. Biol. Chem. 269, 25951-25954

Conflicts of Interest

National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations.