Jordan Jacobelli, PhD Ask a Question Refer Patient Jordan Jacobelli, PhD, is a researcher at National Jewish Health. Dr. Jacobelli is in the Department of Immunology and Genomic Medicine. Assistant Professor Department of Immunology and Genomic Medicine 5280 Top Doctors 2020 Previously a 5280 Top Doctor America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd. Recognized in America’s Top Doctors — Castle Connolly, Inc. Best Doctors in America® 2019-2020 — Best Doctors, Inc. Recognized in Best Doctors in America® — Best Doctors, Inc. America’s Top Doctors 2020 — Castle Connolly Medical, Ltd. Email Profile Print Profile Overview Contact Info & Locations Research Areas Autoimmunity Leukemia/Lymphoma Lymphocyte Migration Special Interests Research Interests My laboratory is interested in understanding how a network of proteins called the cytoskeleton regulates the migration and cell-cell interactions of lymphocytes. In particular we focus on how the cytoskeleton generates the mechanical forces and shape changes required for lymphocyte migration and trafficking during homeostasis and disease. Currently, a research focus of the lab is on a mouse model of multiple sclerosis, a chronic autoimmune-mediated disease of the central nervous system. Our work is aimed at understanding which specific cytoskeletal molecules play a role in lymphocyte exit from the blood flow and entry into the brain and spinal cord. Our goal is to prevent the accumulation of autoreactive lymphocytes in the brain and spinal cord where damage neurons. A second focus of the lab is related to leukemia and lymphoma models. Our goal is to determine how cytoskeletal remodeling mediates the steps required for leukemia and lymphoma cell extravasation and infiltration into tissues to prevent or inhibit metastasis of these types of tumors. My laboratory includes Scott Thompson, PhD student, Robert Long, Lab Researcher and Former Alum, Miriam Estin, PhD (MD/PhD student). See More View Publications Education Education 2002 University of Rome ‘La Sapienza’, Rome, Italy, PhD, Immunology 1997 University of Rome ‘La Sapienza’, Rome, Italy, BS and MS, Biology Publications Wigton E.J., Thompson S.B., Long R.A., Jacobelli J. ‘Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia.’ Journal of Leukocyte Biology. 2016 Jan 20. pii: jlb.1A0815-342R. Beemiller P.J., Jacobelli J., Krummel M.F. ‘Integration of the movement of signaling microclusters with cellular motility in immunological synapses.’ Nature Immunology. 2012. Aug; 13(8):787-95. Friedman R.S., Beemiller P.J., Sorensen C.M., Jacobelli J., Krummel M.F. ‘Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics.’ Journal of Experimental Medicine. 2010 Nov 22;207(12):2733-49. Jacobelli J., Friedman R.S., Conti M.A., Lennon-Dumenil A-M., Piel M., Sorensen C.M., Adelstein R.S., Krummel M.F. ‘Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions.’ Nature Immunology. 2010 Oct;11(10):953-61. Jacobelli J., Bennett F.C., Pandurangi P., Tooley A., Krummel M.F. ‘Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migration.’ Journal of Immunology. 2009 Feb 15;182(4):2041-50. Academic Affiliations Joint appointment through the Immunology Department as Assistant Professor at the University of Colorado Denver. View University of Colorado profile Conflicts of Interest National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations. Ask a Question through Patient Portal Sign in to your My National Jewish Health patient portal account to communicate with your care team, manage appointments, and more. 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