John W. Kappler, PhD Ask a Question Refer Patient John W. Kappler, PhD, is a researcher at National Jewish Health. Dr. Kappler is in the Department of Immunology and Genomic Medicine. Department of Immunology and Genomic Medicine 5280 Top Doctors 2021 Previously a 5280 Top Doctor America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd. Recognized in America’s Top Doctors — Castle Connolly, Inc. Best Doctors in America® 2019-2020 — Best Doctors, Inc. Recognized in Best Doctors in America® — Best Doctors, Inc. America’s Top Doctors 2020 — Castle Connolly Medical, Ltd. Email Profile Print Profile Overview Contact Info & Locations Research Areas Autoimmunity/Rheumatology Basic Immunology Cancer Chronic Beryllium Disease Diabetes, Type-1 Eczema (Atopic Dermatitis) Overview Molecular Immunology Structural Biology News & Videos National Jewish Health Immunologists Win Wolf Prize for Research Promising Vaccine Strategy for Type 1 Diabetes Extended to Humans Researchers Identify Trigger and Mechanism in Type 1 Diabetes Researchers Learn How Beryllium Causes Deadly Lung Disease Education Education 1970 Brandeis University, PhD, Biochemistry 1965 Lehigh University, BA, Chemistry Fellowship 1971 - 1973 University of California at San Diego, Department of Biology, Awards & Recognition 2015: Wolf Prize in Medicine, Wolf Foundation Louisa Gross Horwitz Prize, Columbia University Bonfils-Stanton Foundation Award in Science and Medicine National Jewish Health Lifetime Achievement Award Advisory Editor, Journal of Immunology Ad hoc member NIH Transplantation Biology and Immunology Committee Damon Runyon Foundation for Cancer Research Fellowship Review Committee Professional Memberships American Association of Immunologists American Association for the Advancement of Science National Academy of Sciences Institute of Medicine of the NAS Publications Yang B, Gay DL, Macleod MK, Cao X, Hala T, Sweezer EM, Kappler J, Marrack P, Oliver PM. Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol. 2008 Dec;9(12):1356-63. MacLeod MK, McKee A, Crawford F, White J, Kappler J, Marrack P. CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14521-6. Clambey ET, White J, Kappler JW, Marrack P. Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12997-3002. Dai S, Crawford F, Marrack P, Kappler JW. The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11893-7. Marrack P, Rubtsova K, Scott-Browne J, Kappler JW. T cell receptor specificity for major histocompatibility complex proteins. Curr Opin Immunol. 2008 Apr;20(2):203-7. Academic Affiliations 1993-Present: Distinguished Professor, University of Colorado Denver Teaching & Professional Positions Senior Faculty, Integrated Dept. of Immunology, National Jewish Health and University of Colorado Denver Website Information Kappler Lab Ask a Question through Patient Portal Sign in to your My National Jewish Health patient portal account to communicate with your care team, manage appointments, and more. Create an Account Contact Information Office: 303.398.1322Fax: 303.270.2166 Email: firstname.lastname@example.org Locations National Jewish Health Main Campus 1400 Jackson St. Denver, CO 80206 Patient Ratings The Patient Rating score is an average of all responses to care provider related questions on our independent rating system, the Press Ganey Patient Satisfaction Survey. This survey is about the patient care experience and does not address crucial characteristics like medical decision-making, prescribing the best therapy, and patient outcomes. Responses are measured on a scale of 1 to 5, with 5 being the best score. Learn more about our patient satisfaction survey. Comments Comments are collected in our Press Ganey Patient Satisfaction Surveys. Patients are de-identified to protect confidentiality and patient privacy. Learn more about our patient satisfaction survey.