James R. Hagman, PhD Ask a Question Refer Patient James R. Hagman, PhD, is a researcher at National Jewish Health. Dr. Hagman is in the Department of Immunology and Genomic Medicine. Professor Department of Immunology and Genomic Medicine 5280 Top Doctors 2022 Previously a 5280 Top Doctor America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd. Recognized in America’s Top Doctors — Castle Connolly, Inc. Best Doctors in America® 2019-2020 — Best Doctors, Inc. Recognized in Best Doctors in America® — Best Doctors, Inc. America’s Top Doctors 2020 — Castle Connolly Medical, Ltd. Email Profile Print Profile Overview Contact Info & Locations Research Areas Antibodies B Cells Epigenetics Gene Expression Leukemia/Lymphoma Special Interests Research Interests Regulation of B cell transcription and development Lymphocyte differentiation proceeds through multiple stages characterized by the expression of distinct sets of genes. My laboratory’s goals include understanding how the nuclear proteins Early B cell Factor (EBF) and Pax5 (B cell-specific activator protein) regulate B lineage specification, commitment and the immune response to antigens. EBF has been identified as a crucial factor for lineage determination. EBF regulates many genes (such as mb-1) involved in assembly of the pre-B and mature B cell receptors for antigen (pre-BCR and BCR). We recently identified EBF as an early mediator of changes in mb-1 gene chromatin structure, including DNA demethylation and enhanced accessibility. Pax5 acts downstream of EBF as an important regulator of the early B cell-specific transcriptome, but is also important at later stages of B cell maturation. Notably, Pax5 is a key factor for establishing B cell lineage commitment. To better understand how these proteins function in B cells, my lab employs a combination of biochemical and genetic methods, including transgenic and gene targeted mice. Ultimately, we wish to understand how regulatory signals are integrated for activation and/or repression of genes that contribute to normal immunity, immune diseases, and cancer. Education Education 1989 University of Washington, Seattle, PhD, Microbiology 1986 University of Washington, Seattle, MS, Microbiology 1979 University of California, Berkeley, BA, Genetics Residency Howard Hughes Medical Institute, Postdoctoral University of California, San Francisco, Postdoctoral Awards & Recognition 2009-2013: Member, NIH CMI-B Study Section 2006-2011: Editorial Board, Journal of Biological Chemistry 2008-Present: Advisory Board, Faculty of 1000 Biology 2008: Ad hoc Member, NIH Special Emphasis Panel/Scientific Review Group ZRG1 IMM-J (02) 2007: Research Award, Rocky Mountain Chapter of the Arthritis Foundation 2007: Co-editor, Current Opinion in Immunology, Lymphocyte Development 2000-2001, 2006-2007: Scientific Advisory Board Member, Cancer League of Colorado 2005: Outstanding Scientific Achievement Award, National Jewish Health 1997-2005: Ad hoc Member, NIH Special Emphasis Panel ZRG IMB 01 1997-2001: Peer Review Committee on Development, Differentiation and Cancer, Regular Member, American Cancer Society 1997: Harmon Foundation Award for Arthritis Research 7/1990-6/1993: Fellow of the Leukemia Society of America Professional Memberships The Epigenetics Society American Society for Biochemistry and Molecular Biology Member, American Society of Microbiology Member, American Association of Immunologists Member, American Association for Cancer Research Publications Lukin, K, S Fields, L Guerrettaz, D Straign, V Rodriguez, S Zandi, R Månsson, JC Cambier, M Sigvardsson and J Hagman. 2011. A dose-dependent role for EBF1 in repressing non-B cell specific genes. Eur J Immunol, 41:1787-1793 (PMCID: PMC3127254). Musselman, CA, J Ramirez, JK Sims, RE Mansfield, SS Oliver, JM Denu, JP Mackay, PA Wade, J Hagman and TG Kutateladze. 2012. Bivalent recognition of nucleosomes by the tandem PHD fingers of CHD4 is required for CHD4-mediated repression. Proc Natl Acad Sci USA, 109:787-792 (PMCID: PMC3271909). Hagman, J, J Ramírez and K Lukin. 2012. B lymphocyte lineage specification, commitment and epigenetic control of transcription by Early B cell Factor 1. Curr Topics Micro Immunol, 356:17-38 (PMID: 21735360). Dege, C, and J Hagman. 2012. Activation of Aicda gene transcription by Pax5 in plasmacytoma cells. Immunol Res, [Epub ahead of print] (PMID: 22956488). Ramirez, J, C Dege, KG Kutateladze and J Hagman. 2012. MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexes. Mol Cell Biol, [Epub ahead of print] (PMID: 23071088). 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