Programs & Services
- Alveolar Epithelial Cell Biology
- Childhood Interstitial Lung Disease
- Lung Development
- Pulmonary Surfactant Homeostasis
Research efforts in the Bridges laboratory are focused toward: 1) understanding the molecular regulation of epithelial cell specification and maturation during lung development; and 2) determining the molecular mechanisms that control pulmonary surfactant pool sizes in the postnatal and adult lung, with particular interest in rare pediatric and adult lung diseases associated with surfactant dysfunction. Our lab utilizes state-of-the-art methodologies including CRISPR/Cas9 gene editing in mice, AAV-mediated gene delivery, RNAseq, ATACseq and high content confocal microscopy coupled with physiological and biochemical analyses to address questions of direct clinical relevance.
||University of Cincinnati, Molecular and Developmental Biology, PhD
||University of Colorado at Boulder, Biochemistry, BS
||Cincinnati Children's Hospital, Pulmonary Biology
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