Ivana V. Yang, PhD Ask a Question Refer Patient Ivana V. Yang, PhD, is a researcher at National Jewish Health. Dr. Yang is in the Center for Genes, Environment & Health and Office of Academic Affairs. University Affiliate Office of Academic Affairs Center for Genes, Environment & Health Castle Connolly & 5280 Top Doctors 2023 Previously a 5280 Top Doctor America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd. Recognized in America’s Top Doctors — Castle Connolly, Inc. Best Doctors in America® 2019-2020 — Best Doctors, Inc. Recognized in Best Doctors in America® — Best Doctors, Inc. America’s Top Doctors 2020 — Castle Connolly Medical, Ltd. Email Profile Print Profile Overview Contact Info & Locations Programs & Services Center for Genes, Environment and Health Research Areas Cellular and Molecular Biology Epigenetics Genetic Associations with Musculoskeletal Disease Genetics Genomics Infectious Diseases Inflammation Innate Immunity Interstitial Lung Disease (ILD) Asthma Special Interests Research Interests I share a laboratory with David Schwartz. The focus of the research in the Schwartz/Yang laboratory is on the role of genetics and epigenetics in innate immunity, pulmonary fibrosis, and asthma. One of my specific research interests is the identification of novel innate immune genes in mice by using genetic and genomic approaches and then testing polymorphisms in human orthologs of candidate genes for association with infection in patient cohorts. I am a co-director of another innate immunity project that aims to understand how environmental exposures such as ozone influence the expression of Toll-like receptors (TLRs) in the lung, and how this alteration in TLR expression has profound effects on lung host defense and consequently the development of lung infections and allergic airway disease. I am also co-leading a project aiming to understand the role of epigenetic regulation, specifically DNA methylation, in the development of asthma in humans. Finally, I am participating in the Lung Genomics Research Consortium, a multi-center consortium that aims to establish a comprehensive genetic, molecular, and quantitative clinical phenotyping warehouse for chronic lung diseases. Specifically, I am leading the efforts to perform whole genome methylation profiling and whole genome sequencingof subjects with pulmonary fibrosis and COPD. See More View Curriculum Vitae Education Education 2000 University of North Carolina at Chapel Hill, PhD Fellowship 2001 - 2003 The Institute for Genomic Research, Functional Genomics Awards & Recognition 2003: EU-US Workshop on Molecular Signatures of DNA Damage Induced Stress Response Young Scientist Travel Award 2002: Aspen Cancer Conference Young Investigator 1996: Phi Beta Kappa Publications Yang IV, Alper S, Lackford B, Rutledge H, Warg LA, Burch LH, Schwartz DA. Novel regulators of the systemic response to lipopolysaccharide (LPS). Am J Respir Cell Mol Biol. In press. Yang IV and Schwartz DA. Epigenetic Control of Gene Expression in the Lung. Am. J. Resp. Crit. Care Med. 183:1295-1301 (2011). Yang I.V., Wade C.M., Kang H.M., Alper S., Lackford B., Rutledge H., Eskin, E., Daly, M.J., Schwartz D.A. Identification of Novel Genes that Mediate Innate Immunity using Inbred Mice. Genetics. 183,1535-44 (2009). Huang Y.C.T., Li Z., Carter J.D., Schwartz D.A., Yang I.V. Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages. Am J Respir Cell Mol Biol. 41: 544-52 (2009). Yang, I.V., Burch, L.H., Steele, M.P., Savov, J.D., Hollingsworth, J.W., Berman, K.G., Speer, M.C., Brown, K.K., Schwarz, M.I., Schwartz, D.A. Gene expression profiling of familial and sporadic interstitial pneumonia. Am. J. Resp. Crit. Care Med. 175, 45-54 (2007) (with accompanying editorial). Academic Affiliations Associate Professor, University of Colorado Denver Teaching & Professional Positions 2011-Present: Associate Professor, Department of Medicine, University of Colorado Denver and Center for Genes, Environment and Health, National Jewish Health 2009-2011: Deputy Director, Center for Genes, Environment and Health 2009-2011: Assistant Professor, Department of Medicine, University of Colorado Denver 2008-2011: Assistant Professor, Department of Medicine, National Jewish Health 2005–2008: Staff Scientist, Laboratory of Environmental Lung Disease, National Institute of Environmental Health Sciences (NIEHS) and National Heart Lung and Blood Institute (NHLBI) 2003–2005: Assistant Research Professor, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center Ask a Question through MyChart Sign in to your MyChart account to communicate with your care team, manage appointments, and more. 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