Hua Huang, MD, PhD Ask a Question Refer Patient Dr. Huang is a researcher in the Department of Biomedical Research at National Jewish Health. Professor Department of Biomedical Research 5280 Top Doctors 2019 Previously a 5280 Top Doctor America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd. Recognized in America’s Top Doctors — Castle Connolly, Inc. Best Doctors in America® 2018-2019 — Best Doctors, Inc. Recognized in Best Doctors in America® — Best Doctors, Inc. America’s Top Doctors 2019 — Castle Connolly Medical, Ltd. Email Profile Print Profile × No Rating Available In order to provide the most accurate and useful information on our providers, we only post satisfaction data when a provider has received a minimum of 30 survey responses. We have not yet received the minimum number of surveys for this provider, or this provider is a researcher who only sees a limited number of patients in clinic. To learn more about this survey, visit our about the Press Ganey Survey page. Close Overview Contact Info & Locations Research Areas Basic Immunology Cellular and Molecular Biology Allergy Asthma Special Interests Research Interests Type 2 immunity, characterized by production of type 2 cytokine interleukin (IL)-4, IL-5 and IL-13, is thought to evolve to fight against parasitic infection. However, this type of immunity also causes allergic inflammation, which is the underlying cause of allergic disease, such as food allergy and asthma. Type 2 effectors include CD4+ helper type 2 cells (Th2), CD8+ cytotoxic type 2 cells (TC2), type 2 innate lymphoid cells (ILC2), IgE-producing B cells and type 2 granulocytes that include type 2 cytokine-producing eosinophils, basophils and mast cells. Our lab investigates how type 2 effector cells are made and how type 2 cytokine genes are regulated and applies knowledge gained to understanding why some individuals are more susceptible to develop allergy and asthma and why some allergy and asthma suffers develop more severe form of disease while others do not. We have also been interested in studying gene regulation in other T helper subsets and in the hematopoietic system. Our lab uses cutting edge technologies and innovative approaches to address challenging research questions in the research fields. View more about our current lab projects. See More View Publications Education Education 1993 University of Wisconsin-Madison, PhD, Developmental Biology 1991 University of Wisconsin-Madison, MS, Immunology 1984 Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China, MD Fellowship 1995 - 1999 Leukemia Society Fellow and Postdoctoral fellow, The Laboratory of Immunology, NIAID, NIH, Immunology 1993 - 1995 Leukemia Society Fellow, The Department of Molecular Biology, Princeton University, Stem Cell Biology Awards & Recognition Visiting professor at Fudan University, Sichuan University and Sun Yat-sen University The Lydia Schweppe Immunology Career Development Award NIH K22 Research Career Award Leukemia Society of America Fellowship Visiting Scholarship awarded by the Radiation Effects Research Foundation (Japan) Professional Memberships American Association of Immunology Publications Li, Y., Liu, B., Harmacek, L., Long, Z., Liang, J., Lukin, K., Leach, S., O'Connor, B., Gerber, A. N., Hagman, J., Roers, A. Fred D. Finkelman, F.D., and Huang, H. The transcription factors GATA2 and MITF regulate IgE/mast cell-mediated anaphylaxis by regulating Hdc gene expression in mast cells Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol, published online Dec 22, 2017, 10.1016/j.jaci.2017.10.043. Li Y, Qi X, Liu B, and Huang H. The STAT5-GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and Maintenance. J Immunol. 2015, 194: 4328-38. (Also see Editorial in “In This Issue”) Xiaopeng Qi, Lee Chaves, Yonghua Zhuang, Yuhong Chen, Demin Wang, Jacob Chahon, Brian Graham, Keitaro Ohmori, and Hua Huang. Antagonistic regulation by transcription factors C/EBPa and MITF specifies basophil and mast cell fates. Immunity, 2013, 39, 97-110. Zhihong Chen, Shanze Wang, Nkiruka Erekosima, Jessie Hong, Xiaopeng Qi, Yapeng Li, Patricia Merkel, Vijaya Nagabhushanam, Eugene Choo, Rohit Katial, Rafeul Alam, Hong Wei Chu, Yonghua Zhuang, Meiling Jin, Chunxue Bai, and Hua Huang. IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing Signal Transducer Activator of Transcription 1 signaling. J Allergy Clin Immunol, 2013;132:912-21. (Also see Editor’s Choice of the same issue.) Keitaro Ohmori, Yuchun Luo, Yi Jia, Jun Nishida, Zhengqi Wang, Kevin D. Bunting, Demin Wang, and Hua Huang. IL-3 Induces Basophil Expansion In Vivo by Directing Granulocyte-Monocyte Progenitors to Differentiate into Basophil Lineage-Restricted Progenitors in the Bone Marrow and by Increasing the Number of Basophil/Mast Cell Progenitors in the Spleen. J Immunol 2009, 182: 2835-2841. Academic Affiliations Professor, Department of Immunology & Microbiology, University of Colorado School of Medicine Teaching & Professional Positions Faculty member in the Medical Scientist Training Program and Regenerative Medicine and Stem Cell Biology Program, CU School of Medicine Website Information Huang Lab Ask a Question through Patient Portal Sign in to your My National Jewish Health patient portal account to communicate with your care team, manage appointments, and more. Create an Account Contact Information Office: 877.225.5654Fax: 303.270.2212 Locations National Jewish Health Main Campus 1400 Jackson St. Denver, CO 80206 Patient Ratings The Patient Rating score is an average of all responses to care provider related questions on our independent rating system, the Press Ganey Patient Satisfaction Survey. 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