Hua Huang, MD, PhD

Hua Huang

Dr. Huang is a researcher in the Department of Biomedical Research at National Jewish Health.


Professor
Department of Immunology and Genomic Medicine
Research AreasResearch Areas

Special Interests

Research Interests

My lab studies transcriptional and epigenetic regulation of genes that control immune effector cell development and regulate cytokine and chemokine gene expression. We investigate how super-enhancers and their associated transcription factors integrate signals triggered by various external stimuli, such as antigenic stimulation, infection, cytokine and metabolic products, to generate gene transcription outputs. We also determine the contribution of genetic variants to enhancer activity, gene expression and disease severity. We utilize various cutting-edge technologies, including next-generation sequencing, bioinformatics, enhancer library and CRISPR to address significant research problems in inflammation and allergic immune responses.

View more about our current lab projects.

Education

Education
University of Wisconsin-Madison, PhD, Developmental Biology
University of Wisconsin-Madison, MS, Immunology
Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China, MD
Fellowship
Leukemia Society Fellow and Postdoctoral fellow, The Laboratory of Immunology, NIAID, NIH, Immunology
Leukemia Society Fellow, The Department of Molecular Biology, Princeton University, Stem Cell Biology

Awards & Recognition

Visiting professor at Fudan University, Sichuan University and Sun Yat-sen University
The Lydia Schweppe Immunology Career Development Award
NIH K22 Research Career Award
Leukemia Society of America Fellowship
Visiting Scholarship awarded by the Radiation Effects Research Foundation (Japan)

Professional Memberships

American Association of Immunology

Publications

Li, Y., J. F. Gao, M. Kamran, L. Harmacek, T. Danhorn, S. M. Leach, B. P. O’Connor, J. R. Hagman, and Huang H. GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers. Nature Communications in revision. Preprint, Bioaxiv, 10.1101/2020.09.16.300327, 2020.

Li, Y., Liu, B., Harmacek, L., Long, Z., Liang, J., Lukin, K., Leach, S., O'Connor, B., Gerber, A. N., Hagman, J., Roers, A. Fred D. Finkelman, F.D., and Huang, H. The transcription factors GATA2 and MITF regulate IgE/mast cell-mediated anaphylaxis by regulating Hdc gene expression in mast cells Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol, published online Dec 22, 2017, 10.1016/j.jaci.2017.10.043.

Li Y, Qi X, Liu B, and Huang H.  The STAT5-GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and Maintenance. J Immunol. 2015, 194: 4328-38. (Also see Editorial in “In This Issue”)

Qi X, L. Chaves, Y.H. Zhuang, Y. Chen, D. Wang, J. Chahon, B. Graham, K. Ohmori, and Huang H.  Antagonistic regulation by transcription factors C/EBPa and MITF specifies basophil and mast cell fates.  Immunity, 2013, 39, 97-110.

Ohmori K, Y. Luo, Y. Jia, J. Nishida, Z. Wang, K. D. Bunting, D. Wang, and Huang H.  IL-3 Induces Basophil Expansion In Vivo by Directing Granulocyte-Monocyte Progenitors to Differentiate into Basophil Lineage-Restricted Progenitors in the Bone Marrow and by Increasing the Number of Basophil/Mast Cell Progenitors in the Spleen.  J Immunol 2009, 182: 2835-2841.

Academic Affiliations

Professor, Department of Immunology & Microbiology, University of Colorado School of Medicine

Teaching & Professional Positions

Faculty member in the Medical Scientist Training Program and Regenerative Medicine and Stem Cell Biology Program, CU School of Medicine

Website Information

Huang Lab

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