Hua Huang, MD, PhD Ask a Question Refer Patient Dr. Huang is a researcher in the Department of Biomedical Research at National Jewish Health. Professor Department of Immunology and Genomic Medicine 5280 Top Doctors 2020 Previously a 5280 Top Doctor America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd. Recognized in America’s Top Doctors — Castle Connolly, Inc. Best Doctors in America® 2019-2020 — Best Doctors, Inc. Recognized in Best Doctors in America® — Best Doctors, Inc. America’s Top Doctors 2020 — Castle Connolly Medical, Ltd. Email Profile Print Profile Overview Contact Info & Locations Research Areas Basic Immunology Cellular and Molecular Biology Allergy Asthma Special Interests Research Interests My lab studies transcriptional and epigenetic regulation of genes that control immune effector cell development and regulate cytokine and chemokine gene expression. We investigate how super-enhancers and their associated transcription factors integrate signals triggered by various external stimuli, such as antigenic stimulation, infection, cytokine and metabolic products, to generate gene transcription outputs. We also determine the contribution of genetic variants to enhancer activity, gene expression and disease severity. We utilize various cutting-edge technologies, including next-generation sequencing, bioinformatics, enhancer library and CRISPR to address significant research problems in inflammation and allergic immune responses. View more about our current lab projects. See More View Publications Education Education 1993 University of Wisconsin-Madison, PhD, Developmental Biology 1991 University of Wisconsin-Madison, MS, Immunology 1984 Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China, MD Fellowship 1995 - 1999 Leukemia Society Fellow and Postdoctoral fellow, The Laboratory of Immunology, NIAID, NIH, Immunology 1993 - 1995 Leukemia Society Fellow, The Department of Molecular Biology, Princeton University, Stem Cell Biology Awards & Recognition Visiting professor at Fudan University, Sichuan University and Sun Yat-sen University The Lydia Schweppe Immunology Career Development Award NIH K22 Research Career Award Leukemia Society of America Fellowship Visiting Scholarship awarded by the Radiation Effects Research Foundation (Japan) Professional Memberships American Association of Immunology Publications Li, Y., J. F. Gao, M. Kamran, L. Harmacek, T. Danhorn, S. M. Leach, B. P. O’Connor, J. R. Hagman, and Huang H. GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers. Nature Communications in revision. Preprint, Bioaxiv, 10.1101/2020.09.16.300327, 2020. Li, Y., Liu, B., Harmacek, L., Long, Z., Liang, J., Lukin, K., Leach, S., O'Connor, B., Gerber, A. N., Hagman, J., Roers, A. Fred D. Finkelman, F.D., and Huang, H. The transcription factors GATA2 and MITF regulate IgE/mast cell-mediated anaphylaxis by regulating Hdc gene expression in mast cells Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol, published online Dec 22, 2017, 10.1016/j.jaci.2017.10.043. Li Y, Qi X, Liu B, and Huang H. The STAT5-GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and Maintenance. J Immunol. 2015, 194: 4328-38. (Also see Editorial in “In This Issue”) Qi X, L. Chaves, Y.H. Zhuang, Y. Chen, D. Wang, J. Chahon, B. Graham, K. Ohmori, and Huang H. Antagonistic regulation by transcription factors C/EBPa and MITF specifies basophil and mast cell fates. Immunity, 2013, 39, 97-110. Ohmori K, Y. Luo, Y. Jia, J. Nishida, Z. Wang, K. D. Bunting, D. Wang, and Huang H. IL-3 Induces Basophil Expansion In Vivo by Directing Granulocyte-Monocyte Progenitors to Differentiate into Basophil Lineage-Restricted Progenitors in the Bone Marrow and by Increasing the Number of Basophil/Mast Cell Progenitors in the Spleen. J Immunol 2009, 182: 2835-2841. Academic Affiliations Professor, Department of Immunology & Microbiology, University of Colorado School of Medicine Teaching & Professional Positions Faculty member in the Medical Scientist Training Program and Regenerative Medicine and Stem Cell Biology Program, CU School of Medicine Website Information Huang Lab Ask a Question through Patient Portal Sign in to your My National Jewish Health patient portal account to communicate with your care team, manage appointments, and more. 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