Hua Huang, MD, PhD Ask a Question Refer Patient Hua Huang, MD, PhD is a researcher at National Jewish Health. Dr. Huang is in the Department of Immunology and Genomic Medicine. Professor Department of Immunology and Genomic Medicine 5280 Top Doctors 2022 Previously a 5280 Top Doctor America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd. Recognized in America’s Top Doctors — Castle Connolly, Inc. Best Doctors in America® 2019-2020 — Best Doctors, Inc. Recognized in Best Doctors in America® — Best Doctors, Inc. America’s Top Doctors 2020 — Castle Connolly Medical, Ltd. Email Profile Print Profile Overview Contact Info & Locations Research Areas Basic Immunology Cellular and Molecular Biology Allergy Asthma Special Interests Research Interests My lab studies transcriptional and epigenetic regulation of genes that control immune effector cell development and regulate cytokine and chemokine gene expression. We investigate how super-enhancers and their associated transcription factors integrate signals triggered by various external stimuli, such as antigenic stimulation, infection, cytokine and metabolic products, to generate gene transcription outputs. We also determine the contribution of genetic variants to enhancer activity, gene expression and disease severity. We utilize various cutting-edge technologies, including next-generation sequencing, bioinformatics, enhancer library and CRISPR to address significant research problems in inflammation and allergic immune responses. View more about our current lab projects. See More View Publications Education Education 1993 University of Wisconsin-Madison, PhD, Developmental Biology 1991 University of Wisconsin-Madison, MS, Immunology 1984 Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China, MD Fellowship 1995 - 1999 Leukemia Society Fellow and Postdoctoral fellow, The Laboratory of Immunology, NIAID, NIH, Immunology 1993 - 1995 Leukemia Society Fellow, The Department of Molecular Biology, Princeton University, Stem Cell Biology Awards & Recognition Visiting professor at Fudan University, Sichuan University and Sun Yat-sen University The Lydia Schweppe Immunology Career Development Award NIH K22 Research Career Award Leukemia Society of America Fellowship Visiting Scholarship awarded by the Radiation Effects Research Foundation (Japan) Professional Memberships American Association of Immunology Publications Li YL, Gao JF, Zhao DZ, Guan XY, Morris SC, Finkelman FD, Huang H. The GC box at the proximal enhancer of the Hdc gene is critical for Hdc gene transcription and histamine-mediated anaphylaxis. (BioRxiv 495950) [Preprint], available from: https://doi.org/10.1101/2022.06.13.495950. J Allergy Clin Immunol, published online Feb. 23, 2023, 10.1016/j.jaci.2023.01.031. Li, Y., Gao, J. F., Kamran, M. Harmacek, L., Danhorn, T., Leach, S. M., O'Connor, B. P., Hagman, J. R., Huang H. GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers. Nat Commun 12, 494 (2021). https://doi.org/10.1038/s41467-020-20766-0 Kamran, M.*, Liang, J.Y., 2*, Liu, B., Li, Y., Gao, J.F. Keating, A., Mohamed, F., Dai S.D., Reinhardt, R., Yang, J., Wu, Z.D., Huang H. The Clusters of Transcription Factors NFATC2, STAT5, GATA2, AP1, RUNX1 and EGR2 Binding Sites at the Induced Il13 Enhancers Mediate Il13 Gene Transcription in Response to Antigenic Stimulation. J Immunol, Nov, 13, 2020, 10.4049/jimmunol.2000985. Li Y, Qi X, Liu B, and Huang H. The STAT5-GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and Maintenance. J Immunol. 2015, 194: 4328-38. (Also see Editorial in “In This Issue”) Qi X, L. Chaves, Y.H. Zhuang, Y. Chen, D. Wang, J. Chahon, B. Graham, K. Ohmori, and Huang H. Antagonistic regulation by transcription factors C/EBPa and MITF specifies basophil and mast cell fates. Immunity, 2013, 39, 97-110. A complete list of my publications can be found on ORCID https://ORCID.org/0000-0001-7317-8983 Academic Affiliations Professor, Department of Immunology & Microbiology, University of Colorado School of Medicine Teaching & Professional Positions Faculty member in the Medical Scientist Training Program and Regenerative Medicine and Stem Cell Biology Program, CU School of Medicine Website Information Department of Immunology & Microbiology Colorado University School of Medicine Ask a Question through Patient Portal Sign in to your My National Jewish Health patient portal account to communicate with your care team, manage appointments, and more. Create an Account Contact Information Office: 877.225.5654Fax: 303.270.2212 Patient Ratings The Patient Rating score is an average of all responses to care provider related questions on our independent rating system, the Press Ganey Patient Satisfaction Survey. This survey is about the patient care experience and does not address crucial characteristics like medical decision-making, prescribing the best therapy, and patient outcomes. Responses are measured on a scale of 1 to 5, with 5 being the best score. Learn more about our patient satisfaction survey. Comments Comments are collected in our Press Ganey Patient Satisfaction Surveys. Patients are de-identified to protect confidentiality and patient privacy. Learn more about our patient satisfaction survey.