Evgeny V. Berdyshev, PhD Ask a Question Refer Patient Evgeny V. Berdyshev, PhD, is a researcher at National Jewish Health. Dr. Berdyshev is in the Division of Pulmonary, Critical Care and Sleep Medicine. Associate Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Castle Connolly & 5280 Top Doctors 2023 Previously a 5280 Top Doctor America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd. Recognized in America’s Top Doctors — Castle Connolly, Inc. Best Doctors in America® 2019-2020 — Best Doctors, Inc. Recognized in Best Doctors in America® — Best Doctors, Inc. America’s Top Doctors 2020 — Castle Connolly Medical, Ltd. Email Profile Print Profile Overview Contact Info & Locations Programs & Services Department of Medicine Division of Pulmonary, Critical Care and Sleep Medicine (Adult) Research Areas Pulmonary Fibrosis Asthma Chronic Obstructive Pulmonary Disease (COPD) Special Interests Our laboratory is specialized on mass spectrometric approaches to study the involvement of lipid signaling molecules in the development of different pulmonary diseases. Our main current focus is at sphingolipid signaling molecules as the inducers and modulators of COPD and pulmonary fibrosis. In particular, we have established an important link between sphingolipid de novo biosynthesis and the development of emphysema. We also investigate how natural, synthetic, and endogenous ligands for cannabinoid receptors affect fibrotic processes in the lung. Another focus area for our group is the involvement of polyunsaturated molecular species of lysophosphatidic acids in the allergic responses in the lung. We try to understand metabolic pathways involved and sources of lysophosphatidic acid production in the lung and to link lysophosphatidic acid generation to the severity and subtypes of asthma. See More View Publications Education Education Far East State University (Vladivostock, Russia), PhD Fellowship Pacific Institute of Bioorganic Chemistry (Vladivostok, Russia) , Hormel Institute, University of Minnesota (Austin, MN), Professional Memberships Member of the American Society for Mass Spectrometry (ASMS) Member of the International Cannabinoid Research Society (ICRS) Member of the American Society for Biochemistry and Molecular Biology (ASBMB) Publications Park GY, Lee YG, Berdyshev E, Nyenhuis S, Du J, Fu P, Gorshkova IA, Li Y, Chung S, Karpurapu M, Deng J, Ranjan R, Xiao L, Jaffe HA, Corbridge SJ, Kelly EA, Jarjour NN, Chun J, Prestwich GD, Kaffe E, Ninou I, Aidinis V, Morris AJ, Smyth SS, Ackerman SJ, Natarajan V, Christman JW. (2013) Autotaxin production of lysophosphatidic Acid mediates allergic asthmatic inflammation. Am J Respir Crit Care Med. 188(8):928-40. Gorshkova IA, Wang H, Orbelyan GA, Goya J, Natarajan V, Beiser DG, Vanden Hoek TL, Berdyshev EV. (2013) Inhibition of sphingosine-1-phosphate lyase rescues spingosine kinase-1-knockout phenotype following murine cardiac arrest. Life Sci., 93(9-11):359-66. Gorshkova I., Zhou T., Mathew B., Jacobson J.R., Takekoshi D., Bhattacharya P., Smith B., Aydogan B., Weichselbaum R.R., Natarajan V., Garcia J.G., Berdyshev E.V. (2012) Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. J. Lipid Res. 53(8):1553-1568. Berdyshev, E.V., Gorshkova, I.A., Usatyuk, P., Zhao, Y., Saatian, B., Hubbard, W., Natarajan, V. (2006) De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. Cell. Signaling, 18(10), 1779-1792. Petrache I., Natarajan V., Zhen L., Medler T.R., Richter A., Cho C., Hubbard W.C., Berdyshev E.V., Tuder R.B. (2005) Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nature Med. 11(5), 491-498. Teaching & Professional Positions 2013: Member of the HL 13-023 “Career Development Program for Omics of Lung Diseases” Special Emphasis Panel Review Committee 2006: Chairman of the Supelco-Nicolas Pelick AOCS Award Committee 2004-2005: Member of the Supelco-Nicolas Pelick AOCS Award Committee Ask a Question through MyChart Sign in to your MyChart account to communicate with your care team, manage appointments, and more. Create an Account Contact Information Office: 303.398.1964 Email: BerdyshevE@NJHealth.org Patient Ratings The Patient Rating score is an average of all responses to care provider related questions on our independent rating system, the Press Ganey Patient Satisfaction Survey. This survey is about the patient care experience and does not address crucial characteristics like medical decision-making, prescribing the best therapy, and patient outcomes. Responses are measured on a scale of 1 to 5, with 5 being the best score. Learn more about our patient satisfaction survey. Comments Comments are collected in our Press Ganey Patient Satisfaction Surveys. Patients are de-identified to protect confidentiality and patient privacy. Learn more about our patient satisfaction survey.