Brian P. O'Connor, PhD

Special Interests

Research Interests

In recent years, epigenetic mechanisms, such as histone modification and DNA methylation, have been identified which, translate environmental signals into gene regulation. These molecular epigenetic processes, translate the myriad environmental signals encountered each day, into definitive regulation of our genome, and by extension, who we are at a basic biological level. Dr. O’Connor’s work focuses on understanding at a molecular and organismal level, how epigenetic mechanisms regulate the decision processes governing immune cell activity in the context of disease. The immune system is comprised of multiple types of autonomous cells that must work together to influence the outcome of disease. Currently, Dr. O’Connor’s lab examines the cross talk between environmental stimuli (such as diet or inflammation), the immune system, and disease (such as Asthma).

Website Information

O'Connor Laboratory

Conflicts of Interest

National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations.