Karina A. Serban
Assistant Professor
Department of Medicine
Division of Pulmonary, Critical Care and Sleep Medicine

Special Interests

Clinical interests

chronic obstructive airway diseases (e.g. emphysema, alpha-1 antitrypsin deficiency, combined pulmonary fibrosis and emphysema) and chronic cough

Research interests

I conduct basic and translational research focused on the cross talk between inflammation and immune responses in emphysema and alpha-1 anti-trypsin deficiency. I specifically look at the anti-inflammatory and immuno-modulatory role of alpha-1 antitrypsin on macrophages functions and endothelial cell-monocyte interactions.


Carol Davila University of Medicine and Pharmacy (Bucharest, Romania), M.D.
Marius Nasta National Institute of Pulmonology (Bucharest, Romania) , Pulmonary Medicine
The Chicago Medical School, Rosalind Franklin University of Medicine & Science (North Chicago, IL) , Internal Medicine
Indiana University Purdue University Indianapolis / Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine (Indianapolis, IN) , Pulmonary and Critical Care

Board Certification

10/2013: ABIM Critical Care Medicine Certification Examination
11/2012: ABIM Pulmonary Medicine Certification Examination
8/2010: ABIM Internal Medicine Certification Examination

Professional Memberships

American Thoracic Society


Lockett AD, Petrusca DN, Justice MJ, Poirier C, Serban KA, Rush NI, Kamocka M, Predescu DN, Predescu SA, Petrache I. Scavenger Receptor Class B, Type 1 mediated uptake of Alpha-1 antitrypsin by pulmonary endothelial cells, Am J Physiol Lung Cell Mol Physiol. 2015 Jun 19, [Epub ahead of print], PMID: 26092999

McCaslin CA, Petrusca DN, Poirier C, Serban KA, Anderson GG, Petrache I, Impact of alginate-producing Pseudomonas aeruginosa on alveolar macrophage apoptotic cell clearance, J Cyst Fibros. 2015 Jan; 14(1):70-7, PMID: 25027418

Lockett AD, Brown MB, Santos-Falcon N, Rush NI, Oueini H, Oberle AJ, Bolanis E, Fragoso MA, Petrusca DN, Serban KA, Schweitzer KS, Presson RG Jr, Campos M, Petrache I. Active trafficking of alpha 1 antitrypsin across the lung endothelium, PLoS One. 2014 Apr 17; 9(4), PMID: 24743137.

I Petrache, KA Serban, Emphysema.  Pathobiology of Human Disease, a dynamic encyclopedia of disease mechanism, Elsevier Publishing group, online August, 2014

A Lockett, M Van Demark, Y Gu, K S. Schweitzer, N Sigua, K Kamocki, I Fijalkowska, J Garrison, A Fisher, K Serban, R A. Wise, T Flotte, R G. Presson, H I. Petrache, R M Tuder, I Petrache, Effect of cigarette smoke exposure and structural modifications on the alpha-1 antitrypsin interaction with caspases, Mol. Med, Jan 2012, PMID: 22245800

Hospital Affiliations

  • Rose Medical Center
  • St. Joseph Hospital - Denver
  • Swedish Medical Center

Website Information

Petrache Lab

Contact Information

  • Office: 877.225.5654



  • National Jewish Health Main Campus
    1400 Jackson St.
    Denver, CO 80206

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