It is often difficult to diagnose scleroderma. A specialist in autoimmune diseases (known as a rheumatologist) is usually required to establish the diagnosis. The diagnosis of scleroderma is made based on the careful analysis of many factors.
A thorough history and physical examination are essential and there are also certain laboratory studies that can be helpful when considering the diagnosis, such as specific blood and urine tests. Other tests include specialized lung and heart evaluations are needed to determine if there is any internal organ involvement from scleroderma.
It is important to note that a diagnosis cannot be made based on any specific blood test alone.