Pulmonary Hypertension: Symptoms Make an Appointment Refer a Patient Ask a Question Reviewed by Marjorie Patricia George, MD (July 01, 2019) Healthy pulmonary arteries of the lungs are elastic. They expand and contract with each beat of the heart. In pulmonary hypertension, arteries stiffen and thicken. This leads to increased resistance to blood passing through the vessel, thereby increasing pressure. Higher pulmonary pressure can lead to symptoms of pulmonary hypertension. These symptoms can involve the heart. Common symptoms of pulmonary hypertension may include: Shortness of breath, especially with exertion Fatigue Low oxygen levels Chest pain or pressure Near-fainting/fainting Palpitations Swelling of the ankles or abdomen Heart failure (in advanced cases). Pulmonary Hypertension: Diagnosis Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.