Insect Sting Allergy (Ant, Wasp and Bee Stings): Symptoms Make an Appointment Refer a Patient Ask a Question Reviewed by Kanao Otsu, MD, MPH (April 01, 2019) Reactions to bee stings, wasp stings and ant bites can be immediate or delayed, and they can be toxic or allergic. Immediate Reaction to an Insect Sting Immediate reactions occur within minutes to hours of a bee or other insect sting and can be further divided into local, large local, anaphylactic and toxic reactions. Immediate local reactions are often considered the "normal reaction." Signs and symptoms of immediate localized reactions are limited to the area of the sting site. Local reactions can occur in individuals who are not insect allergic. Signs and symptoms of an immediate reaction may consist of: pain redness swelling mild itching that may last for several hours Delayed Reaction to an Insect Sting Reactions occurring more than four hours after a bee or other insect sting are classified as delayed reactions. There have been isolated reports of serum sickness-like syndromes occurring about a week after a sting. Other unusual reactions that have been reported in association with insect stings include Guillain-Barre syndrome, glomerulonephritis, myocarditis, vasculitis and encephalitis. Signs and symptoms of a delayed reaction may include: hives fever general discomfort joint pain pain or partial paralysis of extremities (hands, arms, feet and legs) kidney pain chest pain (angina) swelling headache, dizziness, loss of consciousness Allergic Reaction to an Insect Sting A true allergic response to a bee or other insect sting happens when the immune system overreacts. It makes specific allergic antibodies to fight the insect venom. Chemicals such as histamine are released that cause the tissue around the bite or sting to swell, turn red, itch and be painful. Large Local Reaction Large local reactions are characterized by redness and swelling that extends from the sting site over a large surrounding area. These reactions often peak within 48 to 72 hours and last up to 10 days. They may be accompanied by fatigue, low-grade fever, mild nausea and discomfort and are often misdiagnosed as cellulitis. Anaphylaxis Anaphylaxis is the most severe insect sting reaction. This reaction, involving multiple organ systems at the same time, most often begins within minutes of the sting, although it can occasionally begin an hour or so later. If an anaphylactic reaction is suspected, give injectable epinephrine and an antihistamine (if available) and call 911 immediately. Signs and symptoms may consist of: flushing, itching hives sneezing, runny nose nausea, vomiting, diarrhea abdominal cramping heart irregularities swelling in the throat severe trouble breathing drop in blood pressure (hypotension) loss of consciousness shock Toxic Reaction In the event of a sting from a poisonous spider or insect or multiple, simultaneous stings from otherwise non-poisonous insects (when a nest is disturbed or when Africanized honeybees are involved); a toxic reaction may result. Toxic reactions are not caused by an allergic response, but rather by the effects of venom that acts as a poison. Local and toxic reactions can be seen in individuals who are not insect sting allergic. Some people who experience toxic reactions can become allergic to insect venom later. Symptoms of a toxic reaction vary depending on the toxicity of the venom of the insect or spider, the amount of venom injected and the individual's tolerance for that particular venom. Signs and symptoms toxic reactions may include: rapid swelling at the site of the sting headache weakness lightheadedness drowsiness fever diarrhea muscle spasms fainting (syncope) seizures Usually, symptoms lessen or go away within 48 hours. Hives and shortness of breath may occur in an allergic reaction, but not in a toxic reaction. It is possible to have both a toxic reaction and an allergic reaction at the same time, but this rarely occurs. A toxic reaction can be life-threatening and may lead to heart problems, shock and death. If a toxic reaction is suspected, call 911, or seek professional medical attention immediately. Insect Sting Allergy (Ant, Wasp and Bee Stings): FAQ Insect Sting Allergy (Ant, Wasp and Bee Stings): Reduce Exposure Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.