Eosinophilic Esophagitis: Diagnosis Make an Appointment Refer a Patient Ask a Question Reviewed by Christine B. Cho, MD (November 01, 2018) How is Eosinophilic Esophagitis (EoE) Diagnosed? The doctor will ask questions about your health and symptoms. Make sure to tell the doctor if anyone in your family has allergies. If family members have allergies, your chances of having allergies increase. Your doctor uses the following information to make a diagnosis of EoE: History of symptoms Family history of symptoms Physical exam Allergy tests Endoscopy - an endoscopy allows the doctor to look inside the esophagus, stomach and upper small intestine. These are the upper portions of the digestive system. The doctor will use a small flexible tube, starting at the mouth, to see inside the body. The doctor may also do a biopsy during the endoscopy. During a biopsy, a small amount of the tissue is taken from the lining of the digestive system. The tissue can be studied closely to help determine the diagnosis and the best treatment. Eosinophilic Esophagitis: Symptoms Eosinophilic Esophagitis: Treatment Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.