Steroids in Eosinophil Negative Asthma (SIENA)

Trial Objective

Most people with asthma have inflammation in their airway. Asthma controller medications, like inhaled corticosteroids, are meant to reduce inflammation in the airway. Reducing airway inflammation should make one's breathing easier. However, many people with asthma don't breathe easier when they take an inhaled corticosteroid. We know that there are several types of cells that can cause airway inflammation. However, inhaled corticosteroids mostly target only one cell called the eosinophil. The purpose of this study is to find out if people should take an asthma controller medication based on the type of inflammatory cells present in their airway.

Study participation involves: 

  • 10 visits to our research unit over ~ 1 year 

  • Asthma and allergy tests at no charge  

  • Asthma medications at no cost


This trial is active and currently recruiting.

How to Participate

For more information, please contact Mary or Allen at 303.398.1443 or complete the form below.

Who Can Participate

Individuals 12 years of age and older who have mild to moderate asthma.

Trial Location

National Jewish Main Campus, Denver, CO



Trial Sponsors

National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)

Principal Investigators

  • image description
    Michael Wechsler, MD, MMSc

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