The PROMISE Study: An Observational Study of Triple Combination Therapy for Cystic Fibrosis

Trial Objective

PROMISE-OB-18 for CFThis is an observational study to evaluate the biological and clinical effects of triple-combination therapy (TCT), elexacaftor/tezacaftor/ivacaftor, in people with cystic fibrosis (CF) before and after starting this therapy, as prescribed by their doctor. Researchers will follow their progress and evaluate the effects of triple-combination therapy in order to understand short and long-term changes caused by the medication to the body and disease.

Enrollment

New enrollment for this trial is temporarily paused

Who Can Participate

Cystic fibrosis patient 12 years or older diagnosed with at least one DF508 CFTR mutation. Must not be using triple-combination therapy before trial.

Age: 12+    Gender: Any Gender


Estimated Time Commitment

6 visits over 25 months



Payment & Reimbursement  

Payment: Provided

Travel Reimbursement: Available

Trial Contact

For more information, contact:

Alix Wilson

Alexandra Wilson
303.270.2321

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Trial Location

National Jewish Main Campus, Denver, CO

Trial Sponsors

Cystic Fibrosis Foundation (CFF), managed by the Therapeutic Development Network Coordinating Center (TDNCC)

Principal Investigators


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After limiting clinical research activity due to safety concerns about COVID-19, we are now restarting clinical research in stages. If you are interested in any of the clinical trials posted on our website, please request trial information. We will respond and share the timing for enrollment resuming. Learn More


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