Investigational Medication Sirolimus for Lymphangioleiomyomatosis (LAM) Request More Information Trial Objective The purpose of this study is to see if a drug called sirolimus slows development of lymphangioleiomyomatosis (LAM), a lung disease in which abnormal cells growing inside the lungs prevent them from working properly. Sirolimus is approved by the United States Food and Drug Administration (FDA) for the treatment of LAM. A recent trial showed that sirolimus stabilized lung function in patients with moderate and severe disease. Our researchers want to find out if giving low-dose sirolimus earlier in the course of treatment safely and effectively prevents further lung damage from LAM. Enrollment New enrollment for this trial is temporarily paused Who Can Participate Adults who have been diagnosed with lymphangioleiomyomatosis are eligible to participate. Age: 18+ Gender: Any Gender Estimated Time Commitment 2 years The study will last for two years and involve seven visits and one phone call, as well as a remote blood draw. Total time commitment is about 9 hours. × Payments are intended to compensate the participant for their time and effort during the study. Payments are typically given to the participant at the end of each completed study visit. Reimbursements are intended to compensate the participant for travel-related expenses. They must be approved by the study staff and require you to turn in receipts. Travel reimbursement will vary from study to study. Payment & Reimbursement Payment: Provided Travel Reimbursement: Available Trial Contact For more information, contact: Jami Henriksen 303.398.1233 Request More Information Trial Location National Jewish Main Campus, Denver, CO Trial Sponsors National Institutes of Health (NIH) Principal Investigators Gregory Downey, MD + × Gregory Downey, MD Professor Executive Vice President, Academic Affairs Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine View Full Profile Patient Rating 4.9 out of 5 stars Make an Appoinment Request More Information After limiting clinical research activity due to safety concerns about COVID-19, we are now restarting clinical research in stages. If you are interested in any of the clinical trials posted on our website, please request trial information. We will respond and share the timing for enrollment resuming. Learn More First Name:* Last Name:* Email Address:* Phone:*
Trial Objective The purpose of this study is to see if a drug called sirolimus slows development of lymphangioleiomyomatosis (LAM), a lung disease in which abnormal cells growing inside the lungs prevent them from working properly. Sirolimus is approved by the United States Food and Drug Administration (FDA) for the treatment of LAM. A recent trial showed that sirolimus stabilized lung function in patients with moderate and severe disease. Our researchers want to find out if giving low-dose sirolimus earlier in the course of treatment safely and effectively prevents further lung damage from LAM.